ID W2KJA4_PHYPR Unreviewed; 6062 AA.
AC W2KJA4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Fibronectin type-III domain-containing protein {ECO:0000259|PROSITE:PS50853};
GN ORFNames=L917_15700 {ECO:0000313|EMBL:ETL84440.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETL84440.1};
RN [1] {ECO:0000313|EMBL:ETL84440.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHvinca01 {ECO:0000313|EMBL:ETL84440.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CHvinca01.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI681777; ETL84440.1; -; Genomic_DNA.
DR EnsemblProtists; ETL84440; ETL84440; L917_15700.
DR VEuPathDB; FungiDB:PPTG_23829; -.
DR VEuPathDB; FungiDB:PPTG_23830; -.
DR Proteomes; UP000054423; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR CDD; cd00063; FN3; 17.
DR Gene3D; 2.60.40.2030; -; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 22.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR PANTHER; PTHR46877:SF14; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR Pfam; PF03160; Calx-beta; 4.
DR Pfam; PF00041; fn3; 9.
DR SMART; SM00237; Calx_beta; 3.
DR SMART; SM00060; FN3; 25.
DR SMART; SM00710; PbH1; 22.
DR SUPFAM; SSF141072; CalX-like; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 15.
DR SUPFAM; SSF51126; Pectin lyase-like; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS50853; FN3; 21.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 5349..5370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5459..5478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5512..5536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5688..5708
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5732..5761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5871..5889
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5901..5920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5932..5953
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 196..293
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 398..509
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 514..607
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 612..702
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 706..797
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 801..889
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 891..985
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1223..1316
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1318..1414
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1419..1516
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1517..1617
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1628..1715
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1721..1812
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1814..1911
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2023..2113
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2355..2449
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2453..2547
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2828..2924
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2929..3021
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3146..3236
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3241..3336
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 3610..3629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6062 AA; 648533 MW; 914FFFB6573DB3AF CRC64;
MGSTGVVIVR NGGVSGQVSV TLISTISSSI RGNRLQKAVT FADGVDNAIV LVNIRSSSAY
GTRRFVLTLT NPTNGASVDS RNLTVTVLDQ GNLSPPGRPL LAQVSSTGGC IGLELGLPTY
LGGWYIGTSI MWHIRVGTGF SYTFEKSDYV VSSISRIDAC GLDLNTSYTI SAALRTDSGT
SESRIIDGFT QALSTPTQVL ELLASPVTSG YAQLSWKAPF DTGGMPITTY EITVLNRATN
EQRIIQVPGS NLTVAISFLL ASTGYMFTVQ AVNEGGLVGP DTRTSVWTDS GSLPKQPPVP
ELISATGGAL RVRVLAPVDC GGSFLMHYAV NVARHTGGIL AYRQYELGTV QSPSYDSNVA
NISIYGLLSN SEYFITVSVE NTQGWSWISE EKIYKTTGPT PVSGIPAPIV ALEDPGELTL
QWNSPLDSGG LGIVGYSIQS RHKYPNGSWS VPEIVYDVRT SLVRTALIMN IVANTEYVFS
VSGYNFRTLC RPDENITPSD ELHITTQSAS VPSQPKNFRM VHVTGGSITL VWDPPRSSGG
EALLWYLIKG GVKYSQLEAM ANVSATMNSL TLYGFDASTF YEFAIAGENS RGCGLYSPSL
YVSTGSVSAP GPPKSLHQIP VASGGIIRLA WEAPKDSGGV KIQQYNILRD DNVVSVVIAV
NGTTTFQDQN NILANKDYNY SVFASNDVAT STNPATITAH SGVASVPGAP SATIEAGSGF
IRLELIPSPD SGGIPFLLFD LTVMRGSVPV DSYNTTRSVF TVTGLYADVL YAVLIQTVNA
RGKSKTTTLT TSTTAATIPD KMSLPRLVNV TGGRLQFEVL PPPNFGGRGV VEYRFYVNET
LNEAIRNSET AYDVVGLTAL TFYAVAVSAT NVVGEGEQSD SLIVTTDTVT APGQVWSLKL
ISKTYEAIEV EWMMPYDTGG NVTAVQFDVE INSSTSDRNL VISTTNRVAL SGLEPATLYT
IQVRAFNLIG EGPWCTSISV TTDPVSPGVI DFEKDAVDVL EDAGSITLTL IRSMGGYMPA
TCTFTTVDGT AIAGDHYVQT SGQVNFSRGT NSQQITIPII DNGMTNDPDQ YFSVSIEEYD
NESGAIGEIS WVNVTITDDG DAGVVAFEQA LYTVSESVST LTVTIVRSGK FSGSGTFAIK
PVDADNGAIE GVDFKIPSEL VILSDQETQS SFNITIINDS TYQERKLFRL KLDVVSGRVA
IADPAAFLTI EILDDGDASP PGLPTSVQVI AVSGGMINLL WVAPEYLGAK NPGELSYSVR
VVEVQSGSTW EQSIKALNLL IPQLKSRAAY GFSVAAKTAF FLGEYTSSVP TLMKEPTPPS
SPMGVRVLSQ TGGMVTLSWS PPFDSGGVDI TSYRVNISTS ADNKTLGNYI TVRNTISIGK
LDPVTNYCAT VESINSYQYV GEASTTVSFT TTSASMPGKP TSLVITKATG GALLVEMAPP
LDTGGAPILY FTLFMTSAQY PTVFRQVYQG ATSSFYATRL LYSTTYKFQY KVTTKVGMSE
LSDIFVAATK FLTLPDEAQN LAIVSRTGGS VTLSWTQPVD FGGTDITAYD VAFFLGYEVK
SQFQQRISGV SVNATLVTAK VVGLQANSTY GFSVSGVNDV SVCEDPSAIR SRTILYSRTN
PAVSLPDTPR GLSVVFVTSG TQTIQWIASE DAGGGSFVAY ILYSDTDTVL YNGTSTTFTR
GSLVKSTVYG YTVCAWNSAG SGVQSSRIFA RTKTDIVAPS QPLNLAQTSH SGGSIGLTWQ
TPLDSGGDTI SGYKLFRNGT WRADIVADSA TMTYLDDQGL AALQYYVYTI RATNSIGLGA
VSEVLIASTA SATVPSAPTR LDVFAKGGNL SATWSPAANS GGMPLTFFRL VVKDDTGVVL
DEVTATTQVS YITYGIRANT TYTVLLTSGN EIGESSATTQ TIMNGAAVRP ATPQVPEQHL
EMTGLARWMI VLKLYFPIDN GGAPLKGLNL YQNGSRIRTV DATSQTEPGD TTIRFTLVEI
GPLHAGFTYH FSTSALSSVE TIGEGGRSDT VKIVMDPANL PSAPNNLRVV LRTAFSVFFE
WDKSDDKGGD DVVYEIAFNN LNTSEPGQVE TNTTAVEVSK LIPGNDYLFR VRARNSAGTS
DWTSDLPAQT DVTQRGVITY KLASSTVFEN VTSVTVQLLR VNGSSSTITC KYSNTSGTAI
YGRDYSLPPD SEHSFTFVGE LIEKSFDVQI INNDIYEPIP RTIGLTLTDT TPDRSDPFPP
TPIIVIIVDD GDAGMISFVV TEVTVLENAR IVSLPLQREY GKSTAVSVQI LVYTGLTSTT
QPDIGFRLPS TTVDFVDGQT SSSASIVIKD NDVYDFPYLC FYLTLEIAAG AARIGTNNVI
KVVVQDDGDR SMPGAMKAPT LDKATGGMLR LKWEPPVNVG GQNVWITGYN VSIRTVKGTT
WIITPTNATV IPFGGLNVLT EYNFSISAIN SIGRGVDSSS VTFSTTKLTA PGPPEHIALL
NRTGGLLTVA VAPPSDSGGA SITGYVVHLA EQGSDFKMAY NGTGHLSSII PVSVTKPNTA
YIIRAQAINV VGVGEMSEPF SFESGPLSRP GPPRLPAIQS SRTGGAIKLD LLPPLDTGTF
TIILGLRERF RQAYYVANGL KITIFRLGAD TTYDMVAVSH LEDSANVITW GRISVSDSRI
TLSDNVATEI VKSGYFDFGG YLFEVDTTQV QSNNTIAYSA SLSTDFGAIA ASSLQNGDEY
DVFVRGPYSD VANYTTVAPT RPGMPPEPDL DYATGGALHI RISWPDDTGG IPITGYEFYI
NNKTVEGTLY HYISQGDFEL KVTVEIGGLV PENNYSFYYI PLNDASACAG DDEDIPKQVI
FSTDVASKPM PIQLIRSTGA TGGGIHVEVK PPNDRGSDQN LTYQIYMSLS RSIPIWTRIY
NDKDISYWQT KLQKVTEYLF MASCMNKVGY SSNSSIYPLR TTLISAPGPP GDLTLINATG
GMIKFSWKSP DDDGGSPITY YSIHAQDTSG NPELALESLL PEISFGGLLA NRVYEFKVFA
GNSLGIGSDA SVKRFSTTLP TPPSLPGDPV VLQSSGGSAT LAIQVPNDTG GVNIDDLVCT
VYENGFKVPV DAVRRLQNMP ITVSRTRRLA TMEVAADGGG FIYLQAGGLL PSTAYSFTIQ
ISNDVGVSDT TNGIATATSV ATVPGAPDPP TITLATGGAL TLSWTDPVDT GGVPLTSYHL
SMARLGEEVG SCEGMIRTCT VGDLLSITDY TVTIFAYNTV GVSPPSEEVT FTTEPTSLPL
APQDVHVAEL SNTSVTIHWD PCIDFGGGYV DTYRLNIVQI SNPSVTFSGI TPVDEQILTI
ENLTPQTEYT ATVRAVTGAG ESGEASKIIF FRTPLYAHQP SPPQVGCHSR KVANVFWEAE
DDAVSYRLFR DGEFYVDNGE DITYEDEIVL GKTYIYQVQV IRFDGSISAL SETTTFTAMT
PVSSGFDCVG NKGHIHWHDY KNLDSETWTI TPQNQAGVLI SFSLFWLECD HDSLTISVTK
GGVTKQLWKG GCHRKGDFVV STGPGLDSVA LSFTSDGSVA YEGMALHYET VDASDAVESV
SAPCPLSPTG FCSLNGACRK GTCSCFSGFI GESCTNAVIC PEDLTTCTST TCDPVCLHSQ
NDVIVVSENG DDTQGTGELM DTSTSGTDPK AVKSLRRALE LATSGQTILL YPGIYTGVDN
CGVTVSTASL LIRGLRGPIP TIVDCKNILR GLIIISDAAP NRLEGFRIQN TLASTDGGAI
KVTDTAVEMK NMVITNANSR QNGGAIYAYQ SQLTFTNVEI TKCSAAKGGA IFLDNSDLIL
DDSIITLSSA SEGGGIYAQN SVSVSGDKDS NLWQNHASIN GGGLCISGSF TGTTLNVLEN
TALVGAGLTA TSGSSTLSGM KVIGNRATNH GGGIAMLNSA NLVLQNSTIQ TNHADRNGGG
VYILSNGSFE NTLASEISNC TAASGGGFYT GDWSRPTVRN LRVVSSSATT SGGCAAFSCS
SATVTNPSFE KCDAAIGGGV YVDAGSKVLL LQASIAECTA TNGAGMYIGS SSVIGGSDVS
SVVRDSHADS AAGGVYITGF HSSIEFFDVQ NCSASIGGGV VAQEASSATM KSVQVVNNKA
TTSGGGLHAQ NSTIQVEPVT VSSNRAVVGG GVYAIDSSLS GIITVDQNNG ERGGGVATSG
ISLLEGATIS ANTASQRGGG VSVETGLFSL RSTIIQSCSV PQGVGGGISI VDADVKHYAL
KIESCASIRG GGIYVNSSSF YQYPTEESTG TSLNAASLTK NRAVEYGGSV FVDGEETTVS
DLVITESHAP FGGGLAAQDA TSCVVLNADI SYSSASTSGG GLLFGSGTSC VIRDSWVMNN
QARESGGGVM IFEATLYHSN VDISNNVAPT AGGVYLNSVL YSASLLSWDD GATQRSRIDA
NIIEPIGGNG ANVVMNCTSN CTLSGCVISG ANLQFGQGAG VFVLGRGNAV ISNSLVANNS
AIKGGGIAVS DAEKTVLENV GFIGNIATDS GGGLWAESSA FLPEVDLMSC VFYNNSAKTS
GGAISLYGVY LYSSVLLVME NHAGNSESGI GGGLFSDKRV NPDRPSSVMA DTWLFLSNDA
PVGGSIAGVK SSEISLLDAN ITRDTGRFFT GTWPHLFSKL VGFEHVEGRA QNKVEVQKGD
LVYLSDRDSV LELLSSFATQ GLAAAGGGIY INANAFFYSQ DSEISSNTAN ERGGSVCLSN
SAQAYFTSVK VILSDSKTSG GGIYVESSSK LYAENSNISD NFADDSGGGI FIDTGDKNAV
TLNGSFIERN FAHGEGCGVF VGREAILAGY KSQFIGNGGV TTSGKNEGGG AISCVDGIVK
LTSCTFINNT ALVGGAIHFD RGGSAAIMSS VFEGNTADQN GGAIATSVKA KVTIALQTLF
ENNVAHFGGA MAVSGTSTFI LTSVDFRSNR ASEVGGALFI TDQAKVTMKA GELAGNIAVF
GGALYSDDHS STSVSDAKFI RNSAFTRGGA IYYQSIDNAT ITRITCKENT APSGGCIFWV
SEDEDLTPTY PCTSCTMEFN EVYDIATNTR DVQVMWWPEN MTSGVPILEP PDEESIQAIK
TRNESLERKM HVWPRLKAVD LYGQVEVLDN QTECMVSDGL CSEQTERLLF EPRALIRSAG
GVISYRGASF TAANRTPEEG IYTTDISCTL PRSERRFFVQ SVKLLPCQPG YSVNQGVCER
CPKNMYSLDG LKCFDCPSGA KCNMNVRRGT DTIAEELGTV SPRTEEGYYL FSAPATKQES
SCNKPSLWKD EDPCKNLALE NPTKNLSDMI YECSNLNDFN VYWSADRLFS CLSGKSFYTC
DVEGACQADV TVQMLAHAAA VSTVSCTSGY DLAICSVCAD GYKRARDNSC LPCNEANAEV
RASIKWQNFV IPVLLVLALI GGVFSVRFYL RDLTEIGLLA KAEADRRLKA PDSKKGGHIA
LRAGAKYRRQ SMAVVGRVDQ VKNKITAFFK TYQSRNVKMV FGVDVSPPPR TFPVNPSKFK
IFIGFFQIFG NFQSSFVVKW SSNVQDVMNI SQKFNLDLVA IAGIDCVVTK NFYFEFTVTV
ILVVLALTVI TAYFYAGMRS YRSKLQLIPR NCLRCGLPVL ESEVIQNDDE SFNPLRLLRS
WWRTYNFYKR SGSSSPVEAA KGGPENEGTA ALSTLKETRA LKRKFGMSQV RTPYLGLFRS
VHAKCPTKRH KLSGAMLDRT IRSNLRVWQA RVKLRMNYLT YRNKCLKLYC WIALFLYPSV
SKTILTVYNC QEVGDVFYLV ADRRLICYNA QWAVFGMIAT IGVIVWVVGI PFFFGLLIWL
AQDRGVAARI KLLRKPQMRM QRHKWLKEVE EQQTADGRFV RDMKNIEVQD EELTKYMKRK
NLTDSTVQAR LGFIYAEYTH DYWWFEVVDL SRKLFLSGVI VFVENGSVEQ VLLALAVCLT
TMWFLLYFQP YDGYSDNLIA SITQLQLFFT LWLGVMIRLN DLNVESLINV QLLSFLLVGT
CIAVTMFGIS MIIGEGLAES RRIFAETTAQ RKKQVQKEVR KRWFQAYNYA AYEAQMLRYG
GQLSFDNVSV PAMLEAFRRT KLNEEEDPEY ASMMPKIEEG DMDESIIESH PEYTTSRVNA
GR
//
