ID   W2KZP5_PHYPR            Unreviewed;      1642 AA.
AC   W2KZP5;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN   ORFNames=L917_11106 {ECO:0000313|EMBL:ETL90074.1};
OS   Phytophthora parasitica (Potato buckeye rot agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4792 {ECO:0000313|EMBL:ETL90074.1};
RN   [1] {ECO:0000313|EMBL:ETL90074.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHvinca01 {ECO:0000313|EMBL:ETL90074.1};
RG   The Broad Institute Genomics Platform;
RA   Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA   Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA   Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Phytophthora parasitica CHvinca01.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KI680390; ETL90074.1; -; Genomic_DNA.
DR   EnsemblProtists; ETL90074; ETL90074; L917_11106.
DR   VEuPathDB; FungiDB:PPTG_12816; -.
DR   Proteomes; UP000054423; Unassembled WGS sequence.
DR   CDD; cd00821; PH; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   PANTHER; PTHR22870; REGULATOR OF CHROMOSOME CONDENSATION; 1.
DR   PANTHER; PTHR22870:SF437; X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR-RELATED; 1.
DR   Pfam; PF00415; RCC1; 5.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00626; RCC1_2; 4.
DR   PROSITE; PS50012; RCC1_3; 6.
PE   4: Predicted;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          6..120
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REPEAT          1303..1363
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          1364..1412
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          1413..1464
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          1465..1531
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          1532..1587
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          1588..1638
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REGION          222..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          594..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1642 AA;  181903 MW;  75D07FA15E5AB15F CRC64;
     MADAAPPRLS GTIWKRNAGI LRAWHSRAAV VTADGFLLYK KKVDAFKTKK IDLAKATFAA
     SIAQANGYYY FELQCGQAQV AIGFSAIQDA RLWLSGMMEA ADENSAGRRA WMANLRRMLT
     LKLRDRRELV PAMADRDWFS EWNFCLRSLK NDREPIAARQ RRLRRLHTIW LQFELFAEIL
     AEIFFSSVQQ RDARGLARIE LFERAASDFA LTGQRPDVSQ TIGDNQEPHP SVLSSAPTSF
     SSTITSTQGN DNDLAATNTY TRRDDVDEMK LAGIHLEFAS KSWQGHKRLT KETALFAKFR
     SLIELFLSES ASDNGKLPSS LRAVLSKLPS FPLVSAFSIR GVSVVAIAEP LRSERSTLAT
     IDNRDLAGLS MALREAKMLR YFPYQELPEL VVRQFPGNVA PTLVRVHPRY DNVLVNSLRS
     SMVHGILIRA VHGVSGNTNR VELLSALDVE ELVETRVPQW IPYLDLVYYQ LDNGESPVEN
     LAVKDFLLQT GRRLTGDVVI TVDAEKSKLL LDLPEAFVMK HDVDIHPLVR KLQGIKKNAE
     IFALAASNPT FSGHSRPVDT SIQMAREYED GVKKLFVQHI KEFAAQLITL GDTTDSKAST
     YGRPRAPTWN QSQSSSRARL TRSNTFSSMP RPEDIFSSSS VQPTEFELIS QPRLQRRMSS
     LSSMAQTISA SGMADSNAGT YVIDTLHLRQ VLREGGVNVR FLPLVFQYLN SRDQLGVQVL
     VASEIVARLA KNLFRYRMLN EDTGKTSRWK SRKSRLIKFI DSIMHGLFHK NLPDGHCSIQ
     ECTGDQFWDI DGPIMYSLGV FSSSFAMDSK APNDVVNSVS SCLDKYRDLL KVNPPILFNS
     LLHVFQARLT KSILPELHEN RFVSVPFLRT EDDLTFNYEE DDPKLAMRIH QDLLWSHLQF
     FRGQFEALKP EIPINTGMAQ GTRTGKLELT TWTQYYRTLS QIFRQSLEHP QLTRLEKAIQ
     SWQDLTSVRA HLSLALRAAA APSYPSGNSK TSAIIREHCS FAYLRMASSK ALFPIEYKLA
     LRCLELVSAG EELVKAMEES DELLEWLRFF YRPANPSQFA KGSSSHPVYS VQYSAGIEFD
     TGIPNDTVTS LREKFQRQQS RQSWMSVMSN VDAYCRRIEA LRRDPVAVAA TRAVLCEMGV
     ASRPISPSSR DHGAVMDVSW ADKYQASFSF HPEDTNMLSS MYSSRGDALW FIECFFLPPL
     ANNSLLVAGD ALVNNEEISS RMTTTRPDTD EGPVPGLALA WGNPLGLSLD EEARISHGAS
     KMSLRLTTEN SSSVRMVSFP PPLRRVVQIA CGYRHTALIT DDRHLYTFGH GECGRLGHGN
     EEDCTDPIPV GYFTSLIAAE GVEFGGVVGV SCGREHTMVV TGNGDLYGFG WGEAGRLGTG
     ETGSSLYPSR VELKNILAVA CGREHTLALT RKGRVFAFGA GFGGRLGNGS EADEELPFLV
     EGLEEYSIAA IDAGECHSCA LSREGEVFTW GFGSSGALGH GARDNCLIPK LVEGPWTNPN
     MDFDGETLTH DISVVVSVKC GSYHTLAATN DGVLYGWGDA AAGQLGVENL TAQDMVVPSP
     TKIRVPTSSG IRGIACGTFT SAVCTTQGHL FMWGSPAAGN GAPLDVEDAH VKRIGVLGEF
     DFSQIACGAY HAVAITRKLE YC
//