ID W2LIW3_PHYPR Unreviewed; 4261 AA.
AC W2LIW3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=EF-hand domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=L917_05362 {ECO:0000313|EMBL:ETL97331.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETL97331.1};
RN [1] {ECO:0000313|EMBL:ETL97331.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHvinca01 {ECO:0000313|EMBL:ETL97331.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CHvinca01.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI678732; ETL97331.1; -; Genomic_DNA.
DR EnsemblProtists; ETL97331; ETL97331; L917_05362.
DR VEuPathDB; FungiDB:PPTG_10274; -.
DR Proteomes; UP000054423; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46961:SF5; DYNEIN HEAVY CHAIN 6; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 965..1371
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1499..1825
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2001..2128
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2347..2428
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2506..2783
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2798..3145
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3174..3397
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3643..3755
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3787..3928
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3936..4257
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3029..3077
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4261 AA; 483744 MW; A2847AD3027A15CF CRC64;
MVDNVRANGN GVRLAPSTSP SKEAARVPIG IVNFEPTVAP VGSPNSPTRR PVIKNSSHIS
SPASYVQLPT GFSVGGGHVL ATVDPAERED GEVEPKVFVP YERVPDLPPR KVEVERKKRL
YESVDVGALL KQRMDDFYSS SVYQKLEMDT SGTAKMVLDS LELYLFDDES YEIHESQEWI
NLGRKCNGSV RIPVTAASYN VRGVVTAWLE AYVVGYNSEK RLFSVEFQRN DKTEVKDCRR
LDVCFKAEDP NNFADRYVAA QLARVQAQNL LRKNFYIDCM PLEELHKLGN ASLGKITRLA
TAVFHGKSLR IPDTTRIVHE IQLNYLRTMC RIVFESHQEM GRNADIFRGF LTKEEEVPAE
PCSRVIVLYT TKSKRTIAPP VDYADQFIGF SFQTFLTSPE ALSALIKVNE ECYRILQLEL
FSVKPGRSVK LEEFQQRQQA LERAVLKTIT EEWSVKVASI IKTSLGSVGK GWYYLQETRQ
DTYDFSKLRS LLRRVNFSMK DTLRFLTDHS LHQFHDFIKN ATLGDVHIVD AKTAFVAYPD
LNRHKLGDIK WQHMCLERQL LAPTSLFTVN LSVSTELYVI NQSEVDAAAQ VHASWRPKDP
EDASEENPHH LIEPKMGHIF SFSTSITMFK TAVLDIFMKM LDNLKNIKQV EQMVMSKLFW
SSMPCLSCVS ANEDWVIALR ESIDALMDKA AVPLRAYLQR YEMYISFINV KEEEYLAEFL
VQQPPNLSMI QEAIKKHYNE ANTVEDVIPT TNVELGMYSI NCLSIRTLLA EKHRRLAKKL
LDLQLKNSIG LAKELLEKFE MVNRQLQKTP QNIEELTEMN AYLEGVPSQI APLLTQSQQL
VKYRLVLDYF QYPYDRDDFM TIWKVRLCPN KINEQMKRMT HMLQMQKTQF LTEMNDQQAE
FAETLRILHG EVDGFRQYTD IARLDQVYKY VVNIEQKIAK ADEDAKLFNS REVLFGQELT
DYDEIQKIRR DFEPYSLLWK TANNWLREHK KWMEGAFLDI NGEEIETFVE ANWASIQKAL
KQFEKLNVKG CSSIAAMIKD SIAEFRPHVP LILSMRNPGM QDRHWSQINQ EIGMTFRPDR
SMKLSYVLEL GLEKHIDAIS RIGETAGKEH QIERTLSSME EQWSGVNLTI VDYRETETFV
VKSVDEIQAL LDEQITTTQA MQFSAFKKPF EERINRWERT LSTVSDVLDE WIQVQRSWLY
LQPIFDSPDI NKQLPTEGKR FATVDKNWRQ TLAAAKQKPS AITFCNNDKL LDRFQESNRF
LEQVQKGLSD FLETKRSAFS RFYFLSNEEL LSILSESKDV KLVQPHLKKC FEGIVSVEFQ
EDLTITAMIS AEGEKVAMTK PVNPVNKNVE NWMTEVEDMM RVSIRDVMYQ AIQDYTKISR
TKWIQKWPGM CVLNGSQFHW TREMEEEMAA SGSDGVKRMM ERQLAQLADM VQMVRGHLDK
LARVSVGALA VIDVHARDVT MRLVNNKVSS KDDFMWSSQL RYYWEDDLFA DMVSARRPYG
YEYLGNSFRL VITPLTDKCY MTLMAALQMT LGGAPAGPAG TGKTETTKDL AKALAKQCVV
FNCSDGLDYI AMGKFFKGLA ACGAWACFDE FNRINIEVLS VIGQQVTTLQ LAIRAGDKRI
MFEGSDIAVN PQFGVFITMN PGYAGRSDLP DSLAALFRPV AMMVPDYAMI GEIMFFAYGY
EKAKQCGAKM VTTFKLCSEM LSSQSHYDYG MRAVKTVITA AGNYKRSDPD MDEEVLLLRA
LQDVNLPKFL AHDIPLFGGI ISDLFPGKSR PQLNLGALIR VIKLTIEKQH LQVHPFFLMK
VIQLYETLCV RHGLMVVGST GGGKSANLNV LADALTELKQ LGEIGHAYEK VIRYQLNPKS
ITMGQLYGEF DANTHEWQDG VLSTLYREAA SDTKSDRKWV IFDGPVDAIW IENMNTVLDD
NKKLCLASGE IIQMSSEMTM MFEVEDLSVA SPATVSRTGM VYMEPSSLGF DPLVMSWLEK
VVRDIGLGSV PSVTQLCLQL HLLLDVYLRP ALQFVTSFVK EWLPQIPSNL VQSLLRLLDC
FFFPMQGDEK KEAKLERVGF YLKNVESFFL FSLIWSVGAT GNDAGRDRFD AYLRDEMIGN
NAKKPFPSAE QVYDYSFDLT KESWVPWLQT IPTFTIDSST SFSELVVPTA DSVRSTFLMN
LTLPLGVHML IVGPTGTGKT INVNHFLEKS NPDKYIPLSM AFSAQSSANQ TQDFIDSKME
KRRKGVFGPT AGKKFIIYVD DLNMPKQEEY FAQPPIEILR QWFDQGGWYD RKLLTFRTII
DVVFVCSMGP PGGGRNPITQ RFVRHFNIMG YTEMSNESKA IVFETIVGNF FSRFSEEIRP
PMIAKKLVQA SIVIYNTVIA ELLPTPAKAH YTFNLRDLAK VFQGVLMGDS KRITKLEQML
RLWVHENMRV FKDRFTTPSD HQWFIELLQT QVSTVFGESL GISGTSTGSK KAAWDLVHPT
PTLFYGDYMV PGADPKVYEE ISDVEKLQAQ VEEYLNDYNA ESSAPMNLVL FMNAIEHVSR
IARVIRQPQG NALLLGVGGS GRQSLTRLAA YMAEYSCTQI EISKGYGVAE WRDDLKKCLM
KAGIDEKPLV FLFSDVQIVH EAMLEDINNV LNSGDVPNLY APEDLDQISQ HCRAYCVKKR
ISPTKLNTFA QYILLVRQNL HLVLCMSPLG SLFRDRIRMF PSLVNCCTID WFSEWPAEAL
QSVAASSLSS GDFQLSGEPS TSTEEESTEA KAAKAAASKA VVSLFQTIHQ SVERESVEFF
EKLRRYNYVT PTSYLELLHT FKTVLLLKRE EVQSKRSRLQ NGVDKIIATK EQVAGMQEQL
VALKPQLEKT QIEVEEMMKQ ITLDKKDADE TKAIVEKEEQ IANKKAAETK EIADDAQRDL
DEALPALEAA VQCLNKLKKS DIDEVKALKN PPHGVKLTME AACIIFGIKP TMKADPDKAG
QKVKDYWESA QKTILGNAKK LMEDMLKFDK DNIGDKIIQE LDRYIEMEEF SPAAVRKASV
ACEAICMWVR AMHTYHNVAK MVEPKKVVLA AAQAELDVTM RVLADAKARL QAVVERLAEL
ERNYNNAVDK KDQLVRDVRQ CEIRLESALK LIGLLGGEET RWAATIRQLN FDYTNLVGDV
IISAATISYL GTFTSEFRES CVSTWYKALE ELKLPHTKGC NIITTLADPV KVRGWQISGL
PSDNLSVQNG LIMARARRWS LLIDPQGQAN RFIKNLGKDS SENGLDVTKL TDKGFLKTLE
NGIRFGKWIL LENVGESLDA TLEPVLLQNK FRQGGQVVMK LGDSTVPYNP AFRFYMTTKL
PNPHYPPETS VKVTLLNFTI TPKGLEDQAL GVVVQEEMPE LAEKKNSLVV ANARMKAELV
EIENKILYML ANSKGNILDD TELIDTLGKA KVTSEDINEK MAEAEITEKA IDESRERYRG
VAFRASLLFF CIADLALVDP MYQYSLPWFV SLFIKSIHSA IESDQLEMRL AHLNDSATYS
LYRNICRSLF EEHKLLFSFL LTIKLLMGSR KIDTLEWRFL ISGSTSSSIE APNPDTTWVE
DRVWREVCAL SSLPAFETLA ASMATNTSQW RKIFDSADPQ VERLPLALDL SLNSFQKLCV
LRCIRPDRMT EAMQNFVAEH IGRRFIEPPP FDLAGSFADS TVITPIIFVL STGSDPAKEL
LVFAETMKMN RKLNSISLGQ GQGPLATKMI EEAVTSGKWV LLQNCHLAIS WMPQLERICD
ELNPDATHRD FRLWLTSRPS TAFPTSVLQN GVKMTKEPPK GIRANLRNSY IKLTNDTLDA
TSKPDQFRKL LFGLSFFHAV VIERKRFGPL GWNIPYAFND TDYDISRAQL EMFLDFYDEV
PYKVLCVMTS VVNYGGRVTD DKDMRTIDVI LEGFFNPQIL EDGYKFSSSG SYYSLTADPD
DPLASYLSYI DDLPLNPEPE VFGMHDNANI TCALAETFHT FDIILALQPR AAVGAGGQSR
ESLIEQQAQS IMSRLPPLFE VEHISLRYPV MYEESMNTVL VQEVQRYNAL LRVLQVSLPN
LQRALRGLIV MSPELEAMAT CLFNQKVPPQ WEKKAYPSLK ALGGWVDDLL ERLQFLTKWV
DNGIPPVFWL SGFFFPQGFL TGILQNHARQ FGLAIDSLSF DFLMQNQIAD SIKTKPEKGG
CYMTGLFLEG ARWDRISHSL VDPLPKELFA RMPVVHLLPT QDRQAPQSGI YRCPVYKILT
RTGTLSTTGH STNFVFWIEI PSDKRTIFRN SLVSETNLQL QFADQDYWIK AGVACFLSLM
Y
//
