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Database: UniProt
Entry: W2LZC4_PHYPR
LinkDB: W2LZC4_PHYPR
Original site: W2LZC4_PHYPR 
ID   W2LZC4_PHYPR            Unreviewed;       686 AA.
AC   W2LZC4;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   ORFNames=L917_00768 {ECO:0000313|EMBL:ETM02859.1};
OS   Phytophthora parasitica (Potato buckeye rot agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4792 {ECO:0000313|EMBL:ETM02859.1};
RN   [1] {ECO:0000313|EMBL:ETM02859.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHvinca01 {ECO:0000313|EMBL:ETM02859.1};
RG   The Broad Institute Genomics Platform;
RA   Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA   Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA   Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Phytophthora parasitica CHvinca01.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
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DR   EMBL; KI677326; ETM02859.1; -; Genomic_DNA.
DR   AlphaFoldDB; W2LZC4; -.
DR   EnsemblProtists; ETM02859; ETM02859; L917_00768.
DR   VEuPathDB; FungiDB:PPTG_00734; -.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR11254:SF440; E3 UBIQUITIN-PROTEIN LIGASE NEDD-4; 1.
DR   PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          349..686
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   ACT_SITE        653
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   686 AA;  77285 MW;  9BF1C8EE6D231FE4 CRC64;
     MEAVLGFLVV LAIIALLFFF LSMLARRAYI RRQRSLELHA PLLNSDDRRL DAALRDAEQG
     FNECTVCSFE NFKRFKFCTV CGEAIVSDEQ DGDRDMNISK KRSTRLSFLP LLKRETKVEL
     VTVTPPKQTT RRRLRAQRRK EWTRKIDVAG CAFWFRDGRW GDTQFTGFVV KFQSTPAMAG
     NGMEKLLPNA VGEGESSLPP SECGTDVVTV ASSVKMDTPD PNPVSAEVNT ESVEQDSTQQ
     PLVGSIDGCI ATLIRGTQEQ HVVLTPSTDT TVDASKLPLG NSTSTEDNAS TPLTEIMALA
     AKDFPSKYAH FVTATSALLI PAEKEHLRLN VERANVFEDS MESLAIIPLQ NVHSVLRINF
     LDESGVDAGG LHREWFVLLN EMLVDPARGL FVCTNENEQT YFLNPCFTAN SLPDQLLHLY
     ATGRLLGRAL LEGSMLCFHL APPLLKLMLG YPLSFADVED LDPEVYTNLR WLLDNENVES
     IGLYFTVTVK EEEKYRDVEL VPGGSSIAVT DSNKREYVER KWQYLLVESV APQLQVFLCG
     LYEIVPRELL LLFDPEEFDF LLCGSDEIDV DDWERNTKYS EGLHHHRSLI WFWELVREMP
     NEYRRRLLQF STGSSRVPLG GFSALTSYDG RLCPFTLKAV SLVGDGFIHS HACFNRLDLP
     LHVVRDELKA VLYATLETEV YGFTTD
//
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