ID W2PNA2_PHYPN Unreviewed; 986 AA.
AC W2PNA2;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Oxoglutarate dehydrogenase (Succinyl-transferring), E1 component {ECO:0000313|EMBL:ETN01729.1};
GN ORFNames=PPTG_17143 {ECO:0000313|EMBL:ETN01729.1};
OS Phytophthora parasitica (strain INRA-310).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=761204 {ECO:0000313|EMBL:ETN01729.1, ECO:0000313|Proteomes:UP000018817};
RN [1] {ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETN01729.1, ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|EMBL:ETN01729.1,
RC ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica INRA-310.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00006936}.
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DR EMBL; KI669623; ETN01729.1; -; Genomic_DNA.
DR RefSeq; XP_008913044.1; XM_008914796.1.
DR AlphaFoldDB; W2PNA2; -.
DR STRING; 761204.W2PNA2; -.
DR EnsemblProtists; ETN01729; ETN01729; PPTG_17143.
DR GeneID; 20186167; -.
DR VEuPathDB; FungiDB:PPTG_17143; -.
DR OrthoDB; 89567at2759; -.
DR Proteomes; UP000018817; Unassembled WGS sequence.
DR GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd02016; TPP_E1_OGDC_like; 1.
DR Gene3D; 3.40.50.12470; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR031717; KGD_C.
DR InterPro; IPR042179; KGD_C_sf.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR Pfam; PF00676; E1_dh; 1.
DR Pfam; PF16870; OxoGdeHyase_C; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000018817};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT DOMAIN 601..831
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 986 AA; 111853 MW; A6FDBA408D9B7273 CRC64;
MLRVLRKGGA VRARPVAVVL RRWKSEKLTP PVQKLSDDIR RSQEETRRVL LLIRTFKQYG
HYVAQIDPLQ KREKLPELER WINGDRWVET PFFDDFNLRS LASKNLLELT THGFTASDLD
REFFIGQDLS IGPVATLREI VTELRELFCG HIGLEYQHLR NRDAALWIRE RLEKYKENQF
SNEEKVDMLR QMVQAELFER FLGRRFSGAK RFSIEGCESL IPGLCELLES ASEHGVEVVQ
MGMAHRGRLN VLANVLQRPL RSIISQFQPY LPDEPDYPNN SDDVRYHLGT SSVIEMRNGK
NLEVTLAANP SHLEAVNPVV LGQARACQTQ LGDDGSRVMP ILIHGDASMF QGSVREALGF
SSLEDFRTGG TIHVIINNQI GFTTLPKNAD SAVYCTDVAK VSRSPIFHVN ADDPEAVAKV
MRIAVEFRQK FQCDVTIDLV CYRRHGHNEQ DSPEITAPIM YHFINKHPTV IKLYSQKLTS
EGALSPKEYV KMCSTFEDHL VSEYHHSREI HSGWDDPGDT SWKTEWYADS KIPNSETPAN
TSNVCDNNDK QIYDRSTGVD QNFLEKVGSQ LFRIPQGFSA HRKVEAIMNN RLRAVETGAR
VDWATAEMLA FGSLLVEGVD VRLSGQDCER GTFNQRHAVL YDQFEALSGR NSSYTPLNNL
DVEGIRSTLQ MTGLESARRG RFDVVNSPLS EEGVLGFEYG YSLQTPMGLT IWEAQFGDFA
NGAQTMIDTF ITTGEQKWQR QSGIVLNLPH GFEGQGPEHS SARLERFLQL VNEDSDEFTG
EQDVNAAITR TNIQVVIPST PAQYFHALRR QVSSSYRKPL IMFTPKSLLH HRPCNSDLAD
LVVGTSFQRV LPPHPDDQVT MVNDDEIRKL VLCCGKIYFP VRHGMRSRGI RDIATARIEQ
LAPFPFHEVA DYIARYPNAE IVWVQEEPKN MGAYSHVLPR LLTVLKYLDD PRKFSYIGRP
PSASPATGQY EIHLQEMKTI VDEALA
//
