ID W2PZX9_PHYPN Unreviewed; 902 AA.
AC W2PZX9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=PPTG_13970 {ECO:0000313|EMBL:ETN06201.1};
OS Phytophthora parasitica (strain INRA-310).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=761204 {ECO:0000313|EMBL:ETN06201.1, ECO:0000313|Proteomes:UP000018817};
RN [1] {ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETN06201.1, ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|EMBL:ETN06201.1,
RC ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica INRA-310.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
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DR EMBL; KI669597; ETN06201.1; -; Genomic_DNA.
DR RefSeq; XP_008908703.1; XM_008910455.1.
DR AlphaFoldDB; W2PZX9; -.
DR STRING; 761204.W2PZX9; -.
DR EnsemblProtists; ETN06201; ETN06201; PPTG_13970.
DR GeneID; 20183286; -.
DR VEuPathDB; FungiDB:PPTG_13970; -.
DR OrthoDB; 1089019at2759; -.
DR Proteomes; UP000018817; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF136; H(+)_CL(-) EXCHANGE TRANSPORTER 6; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000018817};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 43..67
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 87..110
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 207..230
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 242..261
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 332..355
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 470..487
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 529..553
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 785..848
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 678..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 100531 MW; 7F03BBEFC0E526C3 CRC64;
MLWKSTDLES LDYDLFESVV NKSGMGYKYR NGQEKNRLIY ARWFLTLVTG VITALVAVFM
LYFTTLLMSL KQHLLEYTIH HELAKNVLFG TTFWTILAFN LGLVAIAATV TSFGEPVAAG
SGISEVKTTL NGMKIPRMLR LRTFFCKVIG TVCSVAGGLP VGKEGPMIHS GAIVAAGLSQ
GKSSTLGYDT SFSYFAGFRN DREKRDFVAC GAAAGVASAF GAPIGGVLFV LEEGASFWNQ
TLTWRTLFCA MSATFTLAFF LSGMNDNLSW GTLGSHTGSF SFGPFTSSTY QIWEVPLFIL
MGIGGGLQGA FFNGFNTRLA RIRSRWVRTR GVAWMEALLM SVLISSLLFS TPFLLGKCHD
LPQAREDVVH LADTAGAAGA PNKAFVFGME MLKKNGSACI CESCASVSMN GAECFQADET
VQYPYKKELL RFYCPEGQYN DLASLMLTGG ETAIKHLFHA PPDSFDVRNL VVFWFTMLML
ACITYGLKIP SGLFVPALLI GAAYGRLWTR VINYFTSLQH LKAVDPRTYG LVGSLAMLGG
VTRMTISLTV IILECTGNIE FGLPLILTSF FARWVGNYFN EGIYDIHIHL RHVPFLDWNP
PLRGSFLRVK HIMTANPKTL RTVERAGVIF DLLVSTKHNA FPVIVEDPTF GSRFFAGVVL
RKQLNVLLSH NDFSIDKPKP FHRQPHPASS QPDVTPTGGL RYRRPRDLEA NDTPRVDDKL
LESPFASDYC LSYHDMEAHY PRYPIPSPMH QDFRAAARAG RVAGDELYTL SEEDRAMWVD
LTPYMNQTPY LIQEEAPFVR AYRLFRSAGL RHLVVVNRHN NVRGIITRRE LEEEHCSRCF
RLAKNIDTDD VYPLSGAPPV GFFRKLRRTV SRTEQVKRAL SNSVPIVRDN DGDGTELLPR
QV
//
