ID W2QUR8_PHYPN Unreviewed; 1720 AA.
AC W2QUR8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=EF-hand domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PPTG_06417 {ECO:0000313|EMBL:ETN16234.1};
OS Phytophthora parasitica (strain INRA-310).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=761204 {ECO:0000313|EMBL:ETN16234.1, ECO:0000313|Proteomes:UP000018817};
RN [1] {ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETN16234.1, ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|EMBL:ETN16234.1,
RC ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica INRA-310.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; KI669569; ETN16234.1; -; Genomic_DNA.
DR RefSeq; XP_008898581.1; XM_008900333.1.
DR STRING; 761204.W2QUR8; -.
DR EnsemblProtists; ETN16234; ETN16234; PPTG_06417.
DR GeneID; 20176391; -.
DR VEuPathDB; FungiDB:PPTG_06417; -.
DR OMA; TTIALQX; -.
DR OrthoDB; 297674at2759; -.
DR Proteomes; UP000018817; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF62; SODIUM CHANNEL PROTEIN 60E; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018817};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 221..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 516..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 607..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 688..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 929..947
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 967..986
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 998..1015
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1062..1084
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1205..1230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1291..1309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1321..1343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1355..1382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1403..1429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1513..1538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 71..442
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 481..734
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 927..1238
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1288..1547
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1559..1613
FT /note="Voltage-dependent L-type calcium channel IQ-
FT associated"
FT /evidence="ECO:0000259|Pfam:PF16905"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1700..1720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 683
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1179
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1720 AA; 193622 MW; D1FC3FE18B6961F9 CRC64;
MTPPPEAGAP PTTKPPATHT PEHSEKPLQV DLKRRLGFVE PPKRFGADYF LFHFLSREHK
LRRWCVQVVT HKYFDRFIIA AIVANSIILG LSDFSVVDSE LNPASTGKKC QDGGLVDAYS
LQNHIVEISE LPFTIIFTAE CILKIIAMGV HGRGSYGKDM WNVLDFFVVV SSLVASLPGM
PNVSAIRTIR VLRPLRSLSV IPGMRRLIAA LLKALPALGN VVILQIFVFF IFGILGIQLF
GGSMNRRCRL TSFPVKLPLD DMNEAIWPVP KEYIDQVKMN EEAYFCIDAP LLDYEDSAGD
YTKETSPWNT PQSCFWPVDD EDEFLCAAKG QAGNHACNIG KTCGSDYDAF GNPRFSHHKA
MDYALYRPSL DWGLTTFDNI GRAFFTIFQS ITQEGWTVIM YMVMDSSQPT IGAIFFVVLI
IFASFFVMNL TLAVISEEFN LDQKPGKTAA QKREEERRAK LERENAEKLA REHWLNAVVS
HKLFSGFIMA VILANTAILA LDHYPMPTKM DEDLEIVNFA LSCVFVIEMI MKLFGLGLRQ
YSRDRFNLFD AFIVTMGILE TIASPPSFMS SNPPKKGAVS ALRSFRLFRV FKLARDWKSL
RELLEMIIRA VASITNFGVL LFLFIYIYAL VGVQFFGNTM RFDEEGYPTP FNLEEFWNGT
VPRNNFDTLL WAAVTVFQII TGENWNSIMY YAILGNGMLS CVYFISLVIL GDFVLMNLFL
ALLLDNFGDN DEEQEKEKQE ETKKLAQKMS VMNMSMKVAP ITSESERTMT SRGSFLMVST
AFPLGARRQS ILEVDEDGDE EDVRVVNLER FADELTPSVP LAKTVYIETP ARMNPQNGST
TPRVDKLSNF EKSSLRDMVN TARNSILASS RASLVSAMML GTGNQAPDEE TQDDSNNPLT
QINPGRSLFL FAVDSKVRRI ASYLSTHRHF DSTVFGLIVV SSIALAVDNP LADPNSGLAT
FLKGLDKALA IVFAIEMVIK IVAMGLIMHK GAYLRNGWNI IDCVIVVSSI IMLVAESSGK
GANLKSLRSL RGLRTFRPLR MISRRPGLKL VVNALFEAIP EVINVLFVCM LFFLIFSIVA
VNYLKGTFSA CSGDVFNAFS DAQLSFLVSP IAWKDSSALQ RSWFVGTPCE TSFRTTTGSD
LTSEYVCECW GAEWGHVLPQ NFDNVGAAML TFFEISTTEG WADVMMAAID SNGIGMQPVR
DNNMIWALFF VLFIMVGSFF VVNLFVGVII DNFNRMKAAL GGDFMLTPEQ KKWIEAQKAA
SRVGPVRILK PPRQFIRRQL FFLVKMQRFE WFIMICIIVN TFLMAAQFFG ESTLQAYVIN
IVNEIFAVIF TLEAVMKLAA YGWEYFEDQW NQFDFFVVLG TLLSVIVELF TGASVRSLAM
LVRVFRVTRI LRLVKASKSI RQILLTLYIA LPGLSNITSI LFLMLFIYAT MGVQIFAKVA
LSDNIDTHAN FQDFGKGFLF LLRAATGEAW NSCMHDLATS SPGCVDDPPY DPTMCGFNDF
EGCKPLNGCG NPIAYGFFCT FTLLVTYVML NLTIAVILEG FSLSHEDEEP LFEPELLEEF
QTKWADIDPK ATGFVKVDKM LLLVNLLKPP LGKFGMPMDM AHFFKYMCLL EVPLYEGEYV
YFRDVLLAMT REMVKVNAGT ISDMPPDQDP GITGVPGAKR RIEFFAHQYF GARRIQRQVA
EWLRIKRQLE KKYMEEYKNK IKKPSGRPKK QRDARVFTIG
//
