ID W2R5L1_PHYPN Unreviewed; 1660 AA.
AC W2R5L1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETN20683.1};
GN ORFNames=PPTG_03628 {ECO:0000313|EMBL:ETN20683.1};
OS Phytophthora parasitica (strain INRA-310).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=761204 {ECO:0000313|EMBL:ETN20683.1, ECO:0000313|Proteomes:UP000018817};
RN [1] {ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETN20683.1, ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|EMBL:ETN20683.1,
RC ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica INRA-310.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI669564; ETN20683.1; -; Genomic_DNA.
DR RefSeq; XP_008894559.1; XM_008896311.1.
DR STRING; 761204.W2R5L1; -.
DR EnsemblProtists; ETN20683; ETN20683; PPTG_03628.
DR GeneID; 20173784; -.
DR VEuPathDB; FungiDB:PPTG_03628; -.
DR OMA; VDECIFA; -.
DR OrthoDB; 53947at2759; -.
DR Proteomes; UP000018817; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR InterPro; IPR038248; Dicer_dimer_sf.
DR InterPro; IPR005034; Dicer_dimerisation_dom.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR14950; DICER-RELATED; 1.
DR PANTHER; PTHR14950:SF37; ENDORIBONUCLEASE DICER; 1.
DR Pfam; PF03368; Dicer_dimer; 1.
DR Pfam; PF00636; Ribonuclease_3; 2.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS51327; DICER_DSRBF; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018817};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00657}.
FT DOMAIN 670..826
FT /note="Dicer dsRNA-binding fold"
FT /evidence="ECO:0000259|PROSITE:PS51327"
FT DOMAIN 1231..1338
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1404..1607
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT REGION 307..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 712..739
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 309..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..350
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1660 AA; 185698 MW; A5649C2C2E8FA308 CRC64;
MDAALWEHQR EIAAVARHRS VLVSSSQPVG KTFMSCALLS EAASSNSTQV NVVAVAASPS
GRSALQTQLA RLCGHRVLCS DSNTASQWLG DQEFARKQLH NAQVQIAILS PLILQEILRK
KTLDLINVDL LVVKDWDLVH AELPSFFSLL TNLMDEMTTA TTLRIFATST LPASKMDWNP
VTNPLLKHIH VFNMLPVLSS TSMEPSFPPL HCEVFENKDK SIEQDEVSVR DFLLGANDKK
VDLVHVFRME LELGNSAAVY DERKKQDKVN RFIQDAEVVK EHLGQWCLWK FVELELQANL
QACIVDDPDN VNNRKKRKQQ QEDAVDVDDP MDGEGNDDEL DSDEGGEVDE EEVEMVDSSN
VEDNTGKEGM SAQTVKTDRL IARFIGNVGI DESTKLKIRP ILKVLSWLSA QSKVCGTLEA
SSRLLKTAEI VRNRFINSPG TKEIRAWVFL ERRCHCRVVA EYLTAALADL GLPPSCCMLG
SSNARISGAL RFSSFLKVMQ MFTNYTTNIM VTTSVAKKSQ KLRMAPPPCD LVVVMNELLE
PNKLYEFGKR ADITKGFVKY ITEDTVLARK KFEGLVRKMQ EYVRLEQENN RVHGVISEPT
SSATTDSSSL QMPQPPSSST EAAVSSSDST LASLQAEHRL AIIPKPVQPV VNPYELVHRD
TGAILNVTNS VSCLSKFCDT LPGLDTYDRR PQYIVRRISI VKHMAPSLKK AKKKLLKYNS
KLTDKIDALK AEAEQRANAV IDENGDESID GDEESTSSAS SDGRFHFSAT LKLPGALGIK
KQLHSQQVET QDEAKGIVAF KACQELLKKG LLDRHFRSKL LDDQVATIHK DDVGTNSSNG
ETSTGDDTIV LGENDETPAQ LADLSTQSSY DLPPVSAVEL SLRPIRSLTR EAASSSEEGE
EWSTTMCFYG LSGAHYAILA TNELYTGNTN TGWRYDFATS GVMSPEIQPI TLAKYPIKLT
LTKQELHDVL HFHLVVMRLA CMGVQDAVRD VDIASDNVWN EFSEQNDKGY LVVPSVMDES
KQPPTLSLDW DYVREIIGKP LLEPLWPFPT TGATGNAKDP TDEWICVPTY RLNVSYVVEA
VTNRTVDDIR KEYLADEQAW ATHLKKGKST PGNPILGRWQ TRQQLEEADA DQPLIHGIQV
PPIVPIIRRV MQRNNDEGSI AQYKTKFNER LLIPQYTSRL RLTKSRFFDA MGLVPLLYEF
ERKCQISHLM GKIGLELDMT LLDDATTKPA YERLEILGDT FLKLETSWYM YEQRKDIYQE
GQLTQLRRDI IRNDRLNQFA LAARLHHYML YPAEVEQHPF QCWKPSCMGK TPDPVVAPAK
WIADVLEAIT GAYLVGQGEK GARYFLKWIG VSVLEHPSTN FARPFYPDCF PNELYDATMT
SGGAEYPLSL NFKVPQFEDL PKRLMLLQQR LKYTFRNKRL LLEAVTHPSV GQLVLHIDQM
DVNAEGNAGG DVEVMSRSQK KKKTVWKGDY ERLEYLGDAL IEYLTLSYAF LMYDKWLPGS
LSQWKSATVS NDALGKTALA CFGVDECIFA GCVRIDPETM ERVANIERKY ARPEAKTGLS
PAFEAVGVSK KKAKSKSAPS GGNSHTLPKM FADVFEALVA AVFLDSGQDL QLIRDVFMGP
LLNTVEQDAY AYVCHESGLA MDNGGDELME DLVFSSDEED
//
