ID W2RDQ4_PHYPN Unreviewed; 1012 AA.
AC W2RDQ4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Atypical/PI3K/PI4K protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PPTG_21000 {ECO:0000313|EMBL:ETN23356.1};
OS Phytophthora parasitica (strain INRA-310).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=761204 {ECO:0000313|EMBL:ETN23356.1, ECO:0000313|Proteomes:UP000018817};
RN [1] {ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETN23356.1, ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|EMBL:ETN23356.1,
RC ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica INRA-310.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI669562; ETN23356.1; -; Genomic_DNA.
DR RefSeq; XP_008892681.1; XM_008894433.1.
DR AlphaFoldDB; W2RDQ4; -.
DR STRING; 761204.W2RDQ4; -.
DR EnsemblProtists; ETN23356; ETN23356; PPTG_21000.
DR GeneID; 20189599; -.
DR VEuPathDB; FungiDB:PPTG_21000; -.
DR OMA; RVENLWY; -.
DR OrthoDB; 69201at2759; -.
DR Proteomes; UP000018817; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00821; PH; 1.
DR CDD; cd05168; PI4Kc_III_beta; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR015433; PI_Kinase.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018817};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 48..150
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 218..273
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 724..996
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1012 AA; 113405 MW; 8ECCCB5E99AEDABC CRC64;
MPGASATMTE PPAVDVDALL PETPVGAIAT LTSARDKAQA LTHAQHPPRL FGGYLRKRYS
SSMYMGSWRF CVLQGARLRW YRSKECAETD TQLRGEVWVQ SIEPWDGRTA LATYPHAFAV
RTTSKKLLLC TAETQRDRDL WLQHLERALQ RSKSTAELLA AVNSDEGGRR IVPGDMRPPP
TPCAFQERPA AGSDATSIRS APSDLTYGQS LALGDAGCAE CYVRFRPLMT RRVLCGSCAR
AFCARHCSHG IRLQHLGLRA ARRCCDHCTQ RQEFIGYLRS TKRFLGPMVS RGISMDALVA
RSDARNQTGD MFARTLHKLR HGPMTLNRTI KILYQTRKKP HLFRVACERL PFYTETCVDR
VENLWYQLLH LVQCLDAEPA PRCAAQLFYL QRYIRAICRR CPRIALQTIW HAQASVGDGN
YHNLHPHTLL SLLGFIYPNT MLPESSRMFS IWKDLVFADC PEHQLAQILA DLREINAHME
KLISLEPDSM IERWLNAKTL PQFENCAAEM AASGIELCEF QSSILYDSLD VDSSNLSDEP
PGTGIESLVL EQVSFVQSLA AISERLRHIQ PVSDRGKYLA GELETLNNSL QSSALYPLSA
ASDELYQVVR IPPTEGKVFS TKMRAPTLIF VETVPVQSAG AIGLDDTDTE RLRPFVFSSH
PRNSTFFESA VLDEIEASAV SSSGETMLSP YSSSTLATPT PTSTAAGPVT CVENFVYDSK
IFGESWEERK ARIQSESPMG KLPGWDLFSV IVKTNDDLRQ EVFTMQLIHK LKSIFEFEAP
HLWLRTYRIV ATGANIGLLE TITDACSLDH LKKTFPGGNL ADYFRSVYGS DTLSSEFIAA
QRRFIESMAA YSIVSYVLLL KDRHNGNILL SSEGRVIHID FGFILGIAPG GMFSVEDAPF
KLTKEMVDVM GGLGSHGYKH FRNCLYEGFV VLQKYHSEIA ALLQTTGQHS PFPCFHGAKL
ARVITSLRTR LCVGLSRRDI RHRVDQLIRK SYNAWGTRQY DSFQLRSNNI HP
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