ID   W2RKT4_9EURO            Unreviewed;      1315 AA.
AC   W2RKT4;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Hydantoinase B/oxoprolinase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF1541_07902 {ECO:0000313|EMBL:ETN36915.1};
OS   Cyphellophora europaea CBS 101466.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Cyphellophoraceae; Cyphellophora.
OX   NCBI_TaxID=1220924 {ECO:0000313|EMBL:ETN36915.1, ECO:0000313|Proteomes:UP000030752};
RN   [1] {ECO:0000313|EMBL:ETN36915.1, ECO:0000313|Proteomes:UP000030752}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 101466 {ECO:0000313|EMBL:ETN36915.1,
RC   ECO:0000313|Proteomes:UP000030752};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Phialophora europaea CBS 101466.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
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DR   EMBL; KB822724; ETN36915.1; -; Genomic_DNA.
DR   RefSeq; XP_008720447.1; XM_008722225.1.
DR   STRING; 1220924.W2RKT4; -.
DR   GeneID; 19975241; -.
DR   VEuPathDB; FungiDB:HMPREF1541_07902; -.
DR   eggNOG; KOG1939; Eukaryota.
DR   HOGENOM; CLU_002157_0_0_1; -.
DR   InParanoid; W2RKT4; -.
DR   OrthoDB; 674at2759; -.
DR   Proteomes; UP000030752; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030752}.
FT   DOMAIN          14..227
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          250..544
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          671..727
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          750..1283
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
SQ   SEQUENCE   1315 AA;  140878 MW;  85B453D41D68D0A5 CRC64;
     MGSIQQISPV KGIKIAIDRG GTFTDIWATA PGQADLVFKL LSVDPGNYDD APVEAGIRRV
     ISAFTGVEIP RHVPLPKDAI ESIRMGTTVA TNALLERKGT KHAFLVTKGF RDLLPIGYQS
     RPRLFDLNIV KPDVLYSDVC EVDERVTIEA FDEDVDGLFN ATTEEVPGVL ERGLNGQLIR
     VLQPLDRTSL SEQLQRLRTR GFDTVAVCFT HSYVYPKHEL LARQLALDAG FKHVSLSSEV
     AASMIKMVPR GSSASADAYL TPEIKKYLDG FKKGFEGGHL DDVKCEFMQS DGGLVRHDNF
     NGLKGILSGP AGGVVGYART SFDTETKTPV IGFDMGGTST DVSRFGGTFE HVFETTTAGV
     TIQSPQLDIN TVAAGGGSIL AWRNGLFAVG PESASSHPGP ACYRKGGPLT VTDANLFVGR
     LVPESFPSIF GQNENQPLDE EIVKAEFEEL TASINREIGG SLTPQEIACG FLDVANEAMC
     RPIRALTEAK GHSLSSHNLG VFGGAGGQHA CDLAAKLGIR TIIIHRYSSI LSAYGMALAD
     VVQEAQRPHS QVYTDDSRES LNDIFASLQE QVRAKVMAQG IAEDHIRYEY FLNMRYKGTE
     TAMMILESPE SDFKTGFLKR HLQEFNFVFP DDRAILVDDV RVRGIGGSKG TSPDTSRPLQ
     ELRQLTFQAA STKSTSTRTV YFQGQGAQQA PVHILQDLVP GELVKGPAII LDNTQTLVIA
     PGAEAKILTS HVIIDVSTIA KVDISGRMVD PATLSTFGHR FMSIAEQMGR ALQNTSVSLN
     IKERLDFSCA IFGPDAGLVA NAPHVPVHLG SMSYAVRYQH ELLKGKLVPG DVLVSNHPES
     GGTHLPDITV ITPVFDHTGK EVAFYVASRG HHTDIGGLGG TSMPPNSTEL WQEGAAIRSF
     KLVHNGHFDE EGISKILLEP GQHPGCNGSR ALSANISDLK AQVAANNKGS SLIRALMDEW
     SQEVVQLYMS AIQENAAVAV RSFLQETLRL RGPELYAEDA MDNGSLVKLK VTIRPRGDAT
     FDFTGTSCEL LGNMNAPPAI THSALLYCLR LLIGADIPMN QGCLAPATIV LPKGCFLNPS
     AGAAVCAGNT QTSQRVCDVI MKAFQVAGAS QGCMNCLGFF GKGGQDASGK PLSGFAYAFG
     ETICGGSGAT AAADGASAVH THMTNTRITD AELLEKRYPV VLREFSIRAG SGGKGARSGG
     NGAVRDIECR APLTFSVITE RRVTKPYGMR GGGDGERGAN YWVKKAEDGA ERWVNLGPRN
     MVEMGTGDRC VIHTPGGGGF GSPELELGSV AQEKVQWPRA TGSVSAYATA QAEST
//