ID   W2RTI9_9EURO            Unreviewed;       466 AA.
AC   W2RTI9;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Guanine deaminase {ECO:0000256|ARBA:ARBA00014514};
GN   ORFNames=HMPREF1541_05993 {ECO:0000313|EMBL:ETN39767.1};
OS   Cyphellophora europaea CBS 101466.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Cyphellophoraceae; Cyphellophora.
OX   NCBI_TaxID=1220924 {ECO:0000313|EMBL:ETN39767.1, ECO:0000313|Proteomes:UP000030752};
RN   [1] {ECO:0000313|EMBL:ETN39767.1, ECO:0000313|Proteomes:UP000030752}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 101466 {ECO:0000313|EMBL:ETN39767.1,
RC   ECO:0000313|Proteomes:UP000030752};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Phialophora europaea CBS 101466.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; KB822721; ETN39767.1; -; Genomic_DNA.
DR   RefSeq; XP_008718552.1; XM_008720330.1.
DR   AlphaFoldDB; W2RTI9; -.
DR   STRING; 1220924.W2RTI9; -.
DR   GeneID; 19973332; -.
DR   VEuPathDB; FungiDB:HMPREF1541_05993; -.
DR   eggNOG; KOG3968; Eukaryota.
DR   HOGENOM; CLU_012358_0_1_1; -.
DR   InParanoid; W2RTI9; -.
DR   OrthoDB; 65153at2759; -.
DR   UniPathway; UPA00603; UER00660.
DR   Proteomes; UP000030752; Unassembled WGS sequence.
DR   GO; GO:0008892; F:guanine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006147; P:guanine catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 1.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11271; GUANINE DEAMINASE; 1.
DR   PANTHER; PTHR11271:SF6; GUANINE DEAMINASE; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030752}.
FT   DOMAIN          72..464
FT                   /note="Amidohydrolase-related"
FT                   /evidence="ECO:0000259|Pfam:PF01979"
SQ   SEQUENCE   466 AA;  50646 MW;  7D99700485BB7E32 CRC64;
     MSGDQGFHGT LIHSPSPEAI TILEDTLIIV SDRGVITRCD ANISRDTLDR HLAQYAPHIQ
     STAVKRLPTY SFLTPGFVDT HNHAPQYPQR GLGQGLHILD WLSQLTFPNE AKFASPTYAH
     RMYSRAIDTF LQQGTTTASY YGSLHGEATK ILATLCHAKG QRALVGKCNM NRNSPAYYSD
     ASATESLTVT EDFLSHVHAL DPGGDLVRPI LTPRFAISCT DDLLTGLGHL AEANPDLPIQ
     THFNEAQQEI DATLSLFPAS NEADLYDHFR LLTPRTILAH CTIMDTEHEY DVLKGRGCGV
     AHCPIANTTI GGGFMAAPIR RFLDRGINVG LGTDSGGGFS SSILDAIRQA IVVSNAREAQ
     SDGNEKSLSL DEVFYLATLG GAKVCGLGEK IGSFEVGKEL DAMIVRPNLV LGEDSEGKEQ
     VLRDDDGVMT PVEVGDDIRT VWEKWLVSGN DKNIAEVYVK GRRVKG
//