ID W2RWH9_9EURO Unreviewed; 599 AA.
AC W2RWH9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Amine oxidase {ECO:0000256|RuleBase:RU362067};
DE EC=1.4.3.- {ECO:0000256|RuleBase:RU362067};
GN ORFNames=HMPREF1541_04319 {ECO:0000313|EMBL:ETN40044.1};
OS Cyphellophora europaea CBS 101466.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Cyphellophoraceae; Cyphellophora.
OX NCBI_TaxID=1220924 {ECO:0000313|EMBL:ETN40044.1, ECO:0000313|Proteomes:UP000030752};
RN [1] {ECO:0000313|EMBL:ETN40044.1, ECO:0000313|Proteomes:UP000030752}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101466 {ECO:0000313|EMBL:ETN40044.1,
RC ECO:0000313|Proteomes:UP000030752};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Phialophora europaea CBS 101466.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a secondary aliphatic amine + H2O + O2 = a primary amine + an
CC aldehyde + H2O2; Xref=Rhea:RHEA:26414, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478,
CC ChEBI:CHEBI:58855, ChEBI:CHEBI:65296; EC=1.4.3.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000205};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU362067};
CC -!- SIMILARITY: Belongs to the flavin monoamine oxidase family.
CC {ECO:0000256|ARBA:ARBA00005995, ECO:0000256|RuleBase:RU362067}.
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DR EMBL; KB822720; ETN40044.1; -; Genomic_DNA.
DR RefSeq; XP_008716887.1; XM_008718665.1.
DR AlphaFoldDB; W2RWH9; -.
DR STRING; 1220924.W2RWH9; -.
DR GeneID; 19971658; -.
DR VEuPathDB; FungiDB:HMPREF1541_04319; -.
DR eggNOG; KOG0029; Eukaryota.
DR HOGENOM; CLU_004498_0_3_1; -.
DR InParanoid; W2RWH9; -.
DR OrthoDB; 5471885at2759; -.
DR Proteomes; UP000030752; Unassembled WGS sequence.
DR GO; GO:0097621; F:monoamine oxidase activity; IEA:RHEA.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.10.405.10; Guanine Nucleotide Dissociation Inhibitor, domain 1; 1.
DR Gene3D; 3.30.1330.40; RutC-like; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR001613; Flavin_amine_oxidase.
DR InterPro; IPR035959; RutC-like_sf.
DR InterPro; IPR006175; YjgF/YER057c/UK114.
DR PANTHER; PTHR43563; AMINE OXIDASE; 1.
DR PANTHER; PTHR43563:SF14; AMINE OXIDASE; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR Pfam; PF01042; Ribonuc_L-PSP; 1.
DR PRINTS; PR00757; AMINEOXDASEF.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF55298; YjgF-like; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|RuleBase:RU362067};
KW Flavoprotein {ECO:0000256|RuleBase:RU362067};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU362067};
KW Reference proteome {ECO:0000313|Proteomes:UP000030752}.
FT DOMAIN 149..591
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 599 AA; 64796 MW; 93708839B5DCDC4B CRC64;
MAPSTLTIDP PGLMDSRPTF SHVATSLGDN VRFICTAGQV GSDAQGNIPS DRTEQIQLAL
ANLRRCIEAA GATVKDIQKL VYYIVDYDHT RRDHFLPLKA FLNGHRPATS LVPVPKLFKP
GVIFEIEAYL AVPQRSPQNV DVVVVGAGLS GLSAAHQLQE AGFSCAVLEA RNRVGGKTWS
VDATDQGKFV DVGAAWINDT NQSEVFALTK ALGLETVVQN TTGRVVQQDI DGKVSTFVYG
DVPKALSEPG GAQNMLDIRN LTEEVCQKLD VHHPVRIGDD LDNMTLEGWI VSNGGGKTAL
ASATVWTRAM LGMEPKDMSA LFFLNYCKSG GGLMQMRSDL KNGGQYLRLV KGTQSLSIGL
AEQLKPGSLS LDDPVRYIEQ SPSGLHVYSA KGKHTCKRVI VSLPTPLYKD IVFSPALPQD
KLELSQANKL GFINKVLVRY PSPWWREPGL TGMLQSFTGP VSVTRDSSVD PVGSYSLTCF
VAGDAGRALS TLSKAERFKV VTEQIKATLG VAAKVNIPEP TGIEEHEWAH DLWAQGCPCP
AAPPGTMTKY EHALRSSHGK VHFVGTETAY EWKGYMEGAI RSGKRGADEV IRALNLAKL
//
