ID W2RXJ3_9EURO Unreviewed; 829 AA.
AC W2RXJ3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPD {ECO:0000256|ARBA:ARBA00014344};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=HMPREF1541_02974 {ECO:0000313|EMBL:ETN41040.1};
OS Cyphellophora europaea CBS 101466.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Cyphellophoraceae; Cyphellophora.
OX NCBI_TaxID=1220924 {ECO:0000313|EMBL:ETN41040.1, ECO:0000313|Proteomes:UP000030752};
RN [1] {ECO:0000313|EMBL:ETN41040.1, ECO:0000313|Proteomes:UP000030752}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101466 {ECO:0000313|EMBL:ETN41040.1,
RC ECO:0000313|Proteomes:UP000030752};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Phialophora europaea CBS 101466.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: ATP-dependent DNA helicase important for chromosome
CC transmission and normal cell cycle progression in G(2)/M (By
CC similarity). May have a role in changing DNA topology to allow the
CC loading of proteins involved in maintaining sister chromatid cohesion
CC in the vicinity of the centromeres (By similarity). Has a specific role
CC in chromosome segregation during meiosis II.
CC {ECO:0000256|ARBA:ARBA00025396}.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000256|ARBA:ARBA00009146}.
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DR EMBL; KB822719; ETN41040.1; -; Genomic_DNA.
DR RefSeq; XP_008715549.1; XM_008717327.1.
DR AlphaFoldDB; W2RXJ3; -.
DR STRING; 1220924.W2RXJ3; -.
DR GeneID; 19970313; -.
DR VEuPathDB; FungiDB:HMPREF1541_02974; -.
DR eggNOG; KOG1131; Eukaryota.
DR HOGENOM; CLU_011312_1_0_1; -.
DR InParanoid; W2RXJ3; -.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000030752; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR010643; HBB.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR001945; RAD3/XPD.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF1; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF06777; HBB; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR PRINTS; PR00852; XRODRMPGMNTD.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ETN41040.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030752}.
FT DOMAIN 7..283
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 783..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 248..282
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 829 AA; 94234 MW; 4928A21A3CFD14A5 CRC64;
MKFFIDDLPV LFPYGRIYPE QYAYMCDLKR TLDAGGHCVL EMPSGTGKTI SLLSLIVAYQ
QFYPEHRKLI YCSRTMSEIE KALAELKRLM KYRTEQLGHE EEFRGLGLTS RKNLCLHPSV
KREKSGAVVD ARCRSLTAGF VREKKERGDD VEVCVYHDNL DLLEPHNLLP PGVFTLDGLI
QYGEQHKQCP YFSARRMMSF CNVIIYSYHY LLDPKIAERV SKELSKDCIV VFDEAHNIDN
VCIESLSIDL TEDSLRKATR GANNLERKIE EMKDSDEQKL QDEYSKLVEG LREADEARAE
DAFMANPTLP DDLLKEAVPG NIRRAEHFVA FLKRFIEYLK TRMKVLYVIQ ETPPSFLAHL
KELTFIERKP LRFCAERLTS LVRTLELTNI EDYQPLQEVA TFATLAATYE TGFLLILEPF
ETEQAQVPNP ILHFTCLDAS IAIKPVLERF SSVIITSGTI SPLEMYPKML NFSTVLQESY
PMSLARRSFL PLIISKGSDQ QKITSSFGHR SDPGVVRNYG ALLYEFAKIT PDGLVVFFPS
YLYMEMIISM WQGMGVLDQI WQYKLILVET PDAQETSLAL ETYRTACENG KGAILLCVAR
GKVSEGIDFD HHYGRSVLCL GAPYQYTESR ILKARLEFLN DAYRIPPNDF LSFDAMRHAA
QCLGRVLRGK DDYGVMVLAD NRFIKRRNQL PRWISDEILD NHTNLSTDAA VGMARKFLRG
IAQPLESVKK PTGTGVEGLK GKDSWSLEEL EIWQREQDRN RGQGDVGREG VGEWDYMAVD
HKDSELNGNG VHTNGHDAGR GRNYETGAGT DEFGEEVADE DLMIAEAAI
//
