ID W2SB92_9EURO Unreviewed; 687 AA.
AC W2SB92;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=ATP-dependent DNA ligase family profile domain-containing protein {ECO:0000259|PROSITE:PS50160};
GN ORFNames=HMPREF1541_00046 {ECO:0000313|EMBL:ETN45865.1};
OS Cyphellophora europaea CBS 101466.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Cyphellophoraceae; Cyphellophora.
OX NCBI_TaxID=1220924 {ECO:0000313|EMBL:ETN45865.1, ECO:0000313|Proteomes:UP000030752};
RN [1] {ECO:0000313|EMBL:ETN45865.1, ECO:0000313|Proteomes:UP000030752}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101466 {ECO:0000313|EMBL:ETN45865.1,
RC ECO:0000313|Proteomes:UP000030752};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Phialophora europaea CBS 101466.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC {ECO:0000256|ARBA:ARBA00007572}.
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DR EMBL; KB822711; ETN45865.1; -; Genomic_DNA.
DR RefSeq; XP_008710577.1; XM_008712355.1.
DR AlphaFoldDB; W2SB92; -.
DR STRING; 1220924.W2SB92; -.
DR GeneID; 19967385; -.
DR VEuPathDB; FungiDB:HMPREF1541_00046; -.
DR eggNOG; KOG0966; Eukaryota.
DR HOGENOM; CLU_004299_3_0_1; -.
DR InParanoid; W2SB92; -.
DR OrthoDB; 2788069at2759; -.
DR Proteomes; UP000030752; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:InterPro.
DR GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR InterPro; IPR036599; DNA_ligase_N_sf.
DR InterPro; IPR029710; LIG4.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR45997:SF2; ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430); 1.
DR PANTHER; PTHR45997; DNA LIGASE 4; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF04675; DNA_ligase_A_N; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030752}.
FT DOMAIN 377..509
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
FT REGION 656..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..687
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 77274 MW; DEB4898CD9002440 CRC64;
MYFKTLCDFW QTLAGQADEH RREGTIRTWL SSVTADDLKT RSNLLALTSC LFPHRRRDRV
YGLREKSLAD IAIRAWSVGH SRARRLHEWQ SSYGAPDFAA TVRTLVEEGG EVAHVHGPPT
VEEINHVLDH LASSCPYSSP EIRASFQQEI HSPRQGLIDM LQRMSGLEAE WMCRLILGNL
GQVQLPEELV MNFLHSALGA TLQVHDGLVD AVASIMSPRG DGESSMQYQH TAKWRPQLGT
AIRRPTFEKA RSIQHCRQLL GRQPVYVERK YDGEYCQIHV RLLPAGYADI KIFSKSGRDS
TADRTALIPT IRRCLSIGKQ DCQVSTGCVL IGEVVVWNDA QQDIMPFYKI RRYIPRAGRH
LGCGRDSPPL AEEHLMIVLF DCLLLDNVDC VFEPYMQRRH RLACVVRPVP GHAVISEYTT
IDMSSSDATN QITNRLAHAI SHQWEGLIFK PSEATYLTLE GHQQHQVKLR KDMIPGLGDT
ADLVVIGGAH DGNYGASEWW TTFYLACVDL TAGGADDPTL QSFRIVAAVS RPAITITDMQ
FLNRHGKAHY LTPFDVAATP HIETELTGQP PPTAIFMRPL VVEVVGAGFD RLPNSRFESL
RFPRVVKIHL DRSFRDAVTS EQYRHMAERS QHSDINRDGT SFQHWLSRLT ECVNRPDTSR
SASRTASGSA KSSRKRCREI EEVGGVK
//
