ID W2SFD4_NECAM Unreviewed; 372 AA.
AC W2SFD4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Ricin B lectin domain-containing protein {ECO:0000259|Pfam:PF00652};
GN ORFNames=NECAME_15938 {ECO:0000313|EMBL:ETN68238.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN68238.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR EMBL; KI669302; ETN68238.1; -; Genomic_DNA.
DR RefSeq; XP_013290465.1; XM_013435011.1.
DR AlphaFoldDB; W2SFD4; -.
DR STRING; 51031.W2SFD4; -.
DR EnsemblMetazoa; NECAME_15938; NECAME_15938; NECAME_15938.
DR GeneID; 25355964; -.
DR KEGG; nai:NECAME_15938; -.
DR CTD; 25355964; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 1.10.8.460; ppGaNTase-T1 linker domain-like; 1.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11675; N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR11675:SF137; N-ACETYLGALACTOSAMINYLTRANSFERASE 6-RELATED; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 14..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 269..353
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|Pfam:PF00652"
FT REGION 353..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 372 AA; 43593 MW; DE1905A9AA57EBB2 CRC64;
MLPMYKNRRK LRKFLHYLLF LLTFLLIWCT LTIIILYIQD AFRQMIEPSP PVAEHRNSRA
VQVVVGHYNG NLPQEKLRNL TSEEINANNY NPIHGWGEGG KAVRLTKEEE ILSDETFSIN
QFSIFVSDRI ALNRTLGDYR KPSCRSKKYR TFLKYPVLDE AVRAYSVPVK IIRTKDRVGL
IRARLMGAQV LDGNMIRVAE VWMDEWKYLF YKLAPQTAKL RTLVDMSERM ELRRRLQCKS
FKWYLTNVFT DHHMPMDGDF FGRISVGKTK PYCIVNRPGE PGTKKNRLNM SPCTLGSDHW
QFWIYTAEGR LKSDEHMCLS ANQVIHTNGE WAVQLKECAG YENEGWDYNR REEKEGKDIT
NNQSYVGELT KE
//
