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Database: UniProt
Entry: W2SIC6_NECAM
LinkDB: W2SIC6_NECAM
Original site: W2SIC6_NECAM 
ID   W2SIC6_NECAM            Unreviewed;       874 AA.
AC   W2SIC6;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=Ribosomal RNA-processing protein 8 {ECO:0000256|ARBA:ARBA00020203};
GN   ORFNames=NECAME_05308 {ECO:0000313|EMBL:ETN69325.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Ancylostomatoidea; Ancylostomatidae; Bunostominae; Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN69325.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. RRP8 family.
CC       {ECO:0000256|ARBA:ARBA00006301}.
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DR   EMBL; KI669128; ETN69325.1; -; Genomic_DNA.
DR   RefSeq; XP_013291552.1; XM_013436098.1.
DR   AlphaFoldDB; W2SIC6; -.
DR   STRING; 51031.W2SIC6; -.
DR   EnsemblMetazoa; NECAME_05308; NECAME_05308; NECAME_05308.
DR   GeneID; 25345340; -.
DR   KEGG; nai:NECAME_05308; -.
DR   CTD; 25345340; -.
DR   OMA; TIVYEFP; -.
DR   OrthoDB; 5476718at2759; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd01897; NOG; 1.
DR   Gene3D; 1.20.120.1190; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.10.2150; Ribosomal RNA-processing protein 8, N-terminal domain; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR031167; G_OBG.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR041623; NOG1_N.
DR   InterPro; IPR010674; NOG1_Rossman_fold_dom.
DR   InterPro; IPR012973; NOG_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR007823; RRP8.
DR   InterPro; IPR042036; RRP8_N.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR45759:SF1; GTP-BINDING PROTEIN 4; 1.
DR   PANTHER; PTHR45759; NUCLEOLAR GTP-BINDING PROTEIN 1; 1.
DR   Pfam; PF05148; Methyltransf_8; 1.
DR   Pfam; PF06858; NOG1; 1.
DR   Pfam; PF17835; NOG1_N; 1.
DR   Pfam; PF08155; NOGCT; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51710; G_OBG; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT   DOMAIN          170..341
FT                   /note="OBG-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51710"
FT   REGION          491..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   874 AA;  100813 MW;  99FCB3D8171AF5EA CRC64;
     MTSQYNFKRI TVVPTASELK DIVLSKTQRK TPTVVHRQYA IGRIRAFYAR KIKFLQQTLH
     DKLTQIINEF PKMEEVHPFY SDLMNILYDR DHYKIALGQM NTARHLIDGI AREYVRLMKY
     GDSLYRCKML KRAALGRMVK LLKRQKSSFE YLEQVRQHLS RLPSIDPGTR TLILCGFPNV
     GKSSFINSVT RADVEVQPYA FTTKALYVGH LDYKFLRWQV IDTPGILDQP LEERNTIEMQ
     AVTALAHLKA AVLFVMDISE QCDRTIEEQV SLFESIRPLF GNKPVLIGLN KIDIVRRSDL
     PKEKAAQLEK IEGEGVPVIE MSTVTHEGVI NLRDKACDEL LAQRVEAKLQ SKGASVEDTI
     LSRVFVAFPT PRDDKVRAPY IPAAVQRRKQ HMETNENNLE RDESELFSTL SSFLTLRWNV
     EDTRRLEREL ELELEDDYIL DLKKHYLLKN PEEKYDIVPE IWEGHNLADF IDPEIQKVNT
     KRMKNLLGQA QKPQLGKKIK VGRSPSLSAS RPPPRDEVAI PDKKIRAKAA KLRVNAMKRL
     RREARKGEAD RHVMTKISSI SEANAATKTT DAALKRVKRR PWRDKLRKKT RKEAIRADRE
     KLVTKCENEV KPHLDEVSVS KKKRRKRKKT LEICKETPAD GNSEKPIVQD ALKKLEAGRF
     RFLNEQLYNM TGSEALEYFR QDPDAFRCYH NGFAEQVKKW PNHPLNEIIR WLKGKSKQLV
     VYDLGCGDAK IAADVGEMHK VHSFDLVSTN DMVTECDMAH LPSESSVADV VIFCLSLMGT
     NLVDYIKEAR RVLKMGGILK IAEVVSRFVN VKFFCNAVCK LGFAITSKFH LMSCVCLQQH
     ITDYFILMEF RKIEKVENKR PFGLRLKPCA YKKR
//
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