ID W2SIC6_NECAM Unreviewed; 874 AA.
AC W2SIC6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=Ribosomal RNA-processing protein 8 {ECO:0000256|ARBA:ARBA00020203};
GN ORFNames=NECAME_05308 {ECO:0000313|EMBL:ETN69325.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Ancylostomatoidea; Ancylostomatidae; Bunostominae; Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN69325.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. RRP8 family.
CC {ECO:0000256|ARBA:ARBA00006301}.
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DR EMBL; KI669128; ETN69325.1; -; Genomic_DNA.
DR RefSeq; XP_013291552.1; XM_013436098.1.
DR AlphaFoldDB; W2SIC6; -.
DR STRING; 51031.W2SIC6; -.
DR EnsemblMetazoa; NECAME_05308; NECAME_05308; NECAME_05308.
DR GeneID; 25345340; -.
DR KEGG; nai:NECAME_05308; -.
DR CTD; 25345340; -.
DR OMA; TIVYEFP; -.
DR OrthoDB; 5476718at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd01897; NOG; 1.
DR Gene3D; 1.20.120.1190; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.2150; Ribosomal RNA-processing protein 8, N-terminal domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR031167; G_OBG.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR041623; NOG1_N.
DR InterPro; IPR010674; NOG1_Rossman_fold_dom.
DR InterPro; IPR012973; NOG_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR007823; RRP8.
DR InterPro; IPR042036; RRP8_N.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR45759:SF1; GTP-BINDING PROTEIN 4; 1.
DR PANTHER; PTHR45759; NUCLEOLAR GTP-BINDING PROTEIN 1; 1.
DR Pfam; PF05148; Methyltransf_8; 1.
DR Pfam; PF06858; NOG1; 1.
DR Pfam; PF17835; NOG1_N; 1.
DR Pfam; PF08155; NOGCT; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51710; G_OBG; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT DOMAIN 170..341
FT /note="OBG-type G"
FT /evidence="ECO:0000259|PROSITE:PS51710"
FT REGION 491..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 874 AA; 100813 MW; 99FCB3D8171AF5EA CRC64;
MTSQYNFKRI TVVPTASELK DIVLSKTQRK TPTVVHRQYA IGRIRAFYAR KIKFLQQTLH
DKLTQIINEF PKMEEVHPFY SDLMNILYDR DHYKIALGQM NTARHLIDGI AREYVRLMKY
GDSLYRCKML KRAALGRMVK LLKRQKSSFE YLEQVRQHLS RLPSIDPGTR TLILCGFPNV
GKSSFINSVT RADVEVQPYA FTTKALYVGH LDYKFLRWQV IDTPGILDQP LEERNTIEMQ
AVTALAHLKA AVLFVMDISE QCDRTIEEQV SLFESIRPLF GNKPVLIGLN KIDIVRRSDL
PKEKAAQLEK IEGEGVPVIE MSTVTHEGVI NLRDKACDEL LAQRVEAKLQ SKGASVEDTI
LSRVFVAFPT PRDDKVRAPY IPAAVQRRKQ HMETNENNLE RDESELFSTL SSFLTLRWNV
EDTRRLEREL ELELEDDYIL DLKKHYLLKN PEEKYDIVPE IWEGHNLADF IDPEIQKVNT
KRMKNLLGQA QKPQLGKKIK VGRSPSLSAS RPPPRDEVAI PDKKIRAKAA KLRVNAMKRL
RREARKGEAD RHVMTKISSI SEANAATKTT DAALKRVKRR PWRDKLRKKT RKEAIRADRE
KLVTKCENEV KPHLDEVSVS KKKRRKRKKT LEICKETPAD GNSEKPIVQD ALKKLEAGRF
RFLNEQLYNM TGSEALEYFR QDPDAFRCYH NGFAEQVKKW PNHPLNEIIR WLKGKSKQLV
VYDLGCGDAK IAADVGEMHK VHSFDLVSTN DMVTECDMAH LPSESSVADV VIFCLSLMGT
NLVDYIKEAR RVLKMGGILK IAEVVSRFVN VKFFCNAVCK LGFAITSKFH LMSCVCLQQH
ITDYFILMEF RKIEKVENKR PFGLRLKPCA YKKR
//