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Database: UniProt
Entry: W2SJY1_NECAM
LinkDB: W2SJY1_NECAM
Original site: W2SJY1_NECAM 
ID   W2SJY1_NECAM            Unreviewed;       647 AA.
AC   W2SJY1;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   SubName: Full=UDP-glucoronosyl and UDP-glucosyl transferase {ECO:0000313|EMBL:ETN69959.1};
GN   ORFNames=NECAME_14981 {ECO:0000313|EMBL:ETN69959.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Ancylostomatoidea; Ancylostomatidae; Bunostominae; Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN69959.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00000301};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009995}.
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DR   EMBL; KI669018; ETN69959.1; -; Genomic_DNA.
DR   RefSeq; XP_013292186.1; XM_013436732.1.
DR   AlphaFoldDB; W2SJY1; -.
DR   STRING; 51031.W2SJY1; -.
DR   EnsemblMetazoa; NECAME_14981; NECAME_14981; NECAME_14981.
DR   GeneID; 25355008; -.
DR   KEGG; nai:NECAME_14981; -.
DR   CTD; 25355008; -.
DR   OMA; ERVGNQA; -.
DR   OrthoDB; 382054at2759; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR48043:SF23; UDP-GLUCURONOSYLTRANSFERASE; 1.
DR   Pfam; PF00201; UDPGT; 2.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 2.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ETN69959.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..647
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004825951"
FT   TRANSMEM        511..530
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   647 AA;  73954 MW;  BC6A0EEF65B611CC CRC64;
     MNRYCGLLLI SLLTCNAYKF LVYSPIFGYS HMNFMGAIAD TLTEAGHNVT LLMPIMDYEQ
     QDKTGVKLSK NIIKVPTDPE VIELMRYKGE MLGKMWSMEP SLFGLMQVKK RERFVHHFLI
     FNRIPFQMAD NMTKSFTYQC RSKFSVYIEK KRRKAIEFSI FSHHLVLLCL VEIYNDEVLL
     KQLEDEKFDV GIAETFEFCG FGVFELAKIP ATIATFSGVH MDVIAEAIGE PIAPSYVPGA
     MATAGDRMNF VDRFKNILDV VFGKKFFESV FLSQIKAFRK KFGPEFKSYM ELLPQASYVF
     TNSNPYLDYP RPMLHKTVPI GGVTVSFDPK KNKLSANFFR ESLLKVFESM PDTTFIMKYE
     EEGSKIADHL PNVHLSTWFP QNALLADPRL TAFVTHGGLG STTELAHQGK PAILIPIFAD
     QPRNAQMLAK HGGGIVLTKF DLENPHKLKE SLLRIFNDAS FSQNAKRLSE MLVNQPISAK
     QLVVRHSEFA AKFGRLPNLD PYGRHLSFIQ YYLLDVIFVV MSVTLVIVYI STKLLKKCFS
     LALKFFLRDS LLKVFESMPD TTFIMKYEEE GSKIADHLPN VHLSSWFPQN ALLGKLDYIA
     TTYYYTRKDS DGYYFNYLQN SSEPIKKLDK LGRIYEPADI AVSYPAI
//
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