ID W2SJY1_NECAM Unreviewed; 647 AA.
AC W2SJY1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=UDP-glucoronosyl and UDP-glucosyl transferase {ECO:0000313|EMBL:ETN69959.1};
GN ORFNames=NECAME_14981 {ECO:0000313|EMBL:ETN69959.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Ancylostomatoidea; Ancylostomatidae; Bunostominae; Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN69959.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000301};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009995}.
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DR EMBL; KI669018; ETN69959.1; -; Genomic_DNA.
DR RefSeq; XP_013292186.1; XM_013436732.1.
DR AlphaFoldDB; W2SJY1; -.
DR STRING; 51031.W2SJY1; -.
DR EnsemblMetazoa; NECAME_14981; NECAME_14981; NECAME_14981.
DR GeneID; 25355008; -.
DR KEGG; nai:NECAME_14981; -.
DR CTD; 25355008; -.
DR OMA; ERVGNQA; -.
DR OrthoDB; 382054at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF23; UDP-GLUCURONOSYLTRANSFERASE; 1.
DR Pfam; PF00201; UDPGT; 2.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 2.
DR PROSITE; PS00375; UDPGT; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ETN69959.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..647
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004825951"
FT TRANSMEM 511..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 647 AA; 73954 MW; BC6A0EEF65B611CC CRC64;
MNRYCGLLLI SLLTCNAYKF LVYSPIFGYS HMNFMGAIAD TLTEAGHNVT LLMPIMDYEQ
QDKTGVKLSK NIIKVPTDPE VIELMRYKGE MLGKMWSMEP SLFGLMQVKK RERFVHHFLI
FNRIPFQMAD NMTKSFTYQC RSKFSVYIEK KRRKAIEFSI FSHHLVLLCL VEIYNDEVLL
KQLEDEKFDV GIAETFEFCG FGVFELAKIP ATIATFSGVH MDVIAEAIGE PIAPSYVPGA
MATAGDRMNF VDRFKNILDV VFGKKFFESV FLSQIKAFRK KFGPEFKSYM ELLPQASYVF
TNSNPYLDYP RPMLHKTVPI GGVTVSFDPK KNKLSANFFR ESLLKVFESM PDTTFIMKYE
EEGSKIADHL PNVHLSTWFP QNALLADPRL TAFVTHGGLG STTELAHQGK PAILIPIFAD
QPRNAQMLAK HGGGIVLTKF DLENPHKLKE SLLRIFNDAS FSQNAKRLSE MLVNQPISAK
QLVVRHSEFA AKFGRLPNLD PYGRHLSFIQ YYLLDVIFVV MSVTLVIVYI STKLLKKCFS
LALKFFLRDS LLKVFESMPD TTFIMKYEEE GSKIADHLPN VHLSSWFPQN ALLGKLDYIA
TTYYYTRKDS DGYYFNYLQN SSEPIKKLDK LGRIYEPADI AVSYPAI
//