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Database: UniProt
Entry: W2SK28_NECAM
LinkDB: W2SK28_NECAM
Original site: W2SK28_NECAM 
ID   W2SK28_NECAM            Unreviewed;       375 AA.
AC   W2SK28;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial {ECO:0000256|ARBA:ARBA00019998};
GN   ORFNames=NECAME_05084 {ECO:0000313|EMBL:ETN69898.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Ancylostomatoidea; Ancylostomatidae; Bunostominae; Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN69898.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ECSIT family.
CC       {ECO:0000256|ARBA:ARBA00007674}.
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DR   EMBL; KI669035; ETN69898.1; -; Genomic_DNA.
DR   RefSeq; XP_013292125.1; XM_013436671.1.
DR   AlphaFoldDB; W2SK28; -.
DR   STRING; 51031.W2SK28; -.
DR   EnsemblMetazoa; NECAME_05084; NECAME_05084; NECAME_05084.
DR   GeneID; 25345116; -.
DR   KEGG; nai:NECAME_05084; -.
DR   CTD; 25345116; -.
DR   OMA; EEDFSHW; -.
DR   OrthoDB; 4098911at2759; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR029342; ECIST_C.
DR   InterPro; IPR010418; ECSIT.
DR   InterPro; IPR046448; ECSIT_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13113; ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS; 1.
DR   PANTHER; PTHR13113:SF1; EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL; 1.
DR   Pfam; PF14784; ECSIT_C; 1.
DR   Pfam; PF06239; ECSIT_N; 1.
DR   SMART; SM01284; ECSIT_Cterm; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          244..365
FT                   /note="ECSIT C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01284"
SQ   SEQUENCE   375 AA;  44088 MW;  FF57C9F741AB7445 CRC64;
     MLGRSLLGLQ RCILESCAPF ASSTSEFAKE QTSLIHIDKH FDSVPKIERN KDTFLAAIAA
     FKEKKPRGHV EFINTALKYI KEYGIHKDLD VYKALLDVFP KGKMIPQNTF QRIFLHYPMQ
     QNCCVKVLDE MEWNGVQPDK EIHDIVVNAF GEWNFATRKV KRMLYWMPKL KYSNKYLDRR
     DVEGKGLSAP ELAGIALKMM SRDPGTELTL TRVRHLIYVW YESCAFKLAS EGPQDNRWFA
     TAQSLTQRNL IRGLHDETEV FIDGPFKVYV MEHQVEYIVM TCAPLHTHHN EFKKEEFEED
     FSHWFSEWKR ESLERKRSVH EQKHETILAM GALYMNDNRT ASLWLERLHE ENPSLKKLKT
     RLRLDKNEKH NTSFS
//
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