ID W2SKS6_NECAM Unreviewed; 419 AA.
AC W2SKS6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETN69327.1};
GN ORFNames=NECAME_05310 {ECO:0000313|EMBL:ETN69327.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN69327.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004492}.
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DR EMBL; KI669128; ETN69327.1; -; Genomic_DNA.
DR RefSeq; XP_013291554.1; XM_013436100.1.
DR AlphaFoldDB; W2SKS6; -.
DR STRING; 51031.W2SKS6; -.
DR EnsemblMetazoa; NECAME_05310; NECAME_05310; NECAME_05310.
DR GeneID; 25345342; -.
DR KEGG; nai:NECAME_05310; -.
DR CTD; 25345342; -.
DR OMA; XANSEEF; -.
DR OrthoDB; 5491867at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23323:SF24; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR PROSITE; PS50236; CHCR; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 419 AA; 47751 MW; 9E3ADF35906E121D CRC64;
MVFFYEADQC TEADGYRGRC LQLGRSHEKL QLLALGEHLV LLTKQHALIP SNDEAEFMSM
VTVYNVKGQY IGFSCSIPSL CRLFTVDQCL MILSKDGTLS ELTEKNLSAK LDILFKKNLY
DVAVILAKSS KDGAEHLKSI HAKYGDYLYG KGDFDNAVSE YKETIGMLEP SYVIKRYLDG
SRLRQLCVYL EALHDTDCYT LYHTNILLNC YAQLEERKKM KKFLEKIAVD GKTDMNSVFE
VLRSLKVSED ASFLAVKLNM HDHALSMMIE DLGRHSTAVK YIEKRPPEEA SIENTDLACP
DETMELLQHL IDESPKSVDP TQLLKVFIND FAKSTAFIEF ALKKILLLFR IETSGILHPL
VVLEVLSRSN TLTVAAVKDY IIKWLDAQKK QIESDQKAIV EGERRMQEVD KQIESLKFK
//
