ID W2SL26_NECAM Unreviewed; 302 AA.
AC W2SL26;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Nematode cuticle collagen domain protein {ECO:0000313|EMBL:ETN70364.1};
GN ORFNames=NECAME_14807 {ECO:0000313|EMBL:ETN70364.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN70364.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI668968; ETN70364.1; -; Genomic_DNA.
DR RefSeq; XP_013292591.1; XM_013437137.1.
DR AlphaFoldDB; W2SL26; -.
DR STRING; 51031.W2SL26; -.
DR EnsemblMetazoa; NECAME_14807; NECAME_14807; NECAME_14807.
DR GeneID; 25354834; -.
DR KEGG; nai:NECAME_14807; -.
DR CTD; 25354834; -.
DR OMA; IEADFCK; -.
DR OrthoDB; 2882715at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042302; F:structural constituent of cuticle; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR Gene3D; 1.20.5.320; 6-Phosphogluconate Dehydrogenase, domain 3; 1.
DR InterPro; IPR002486; Col_cuticle_N.
DR InterPro; IPR008160; Collagen.
DR PANTHER; PTHR24637:SF288; COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24637; COLLAGEN; 1.
DR Pfam; PF01484; Col_cuticle_N; 1.
DR Pfam; PF01391; Collagen; 3.
DR SMART; SM01088; Col_cuticle_N; 1.
PE 4: Predicted;
KW Collagen {ECO:0000313|EMBL:ETN70364.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..63
FT /note="Nematode cuticle collagen N-terminal"
FT /evidence="ECO:0000259|SMART:SM01088"
FT REGION 75..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..125
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..275
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 302 AA; 30282 MW; 4ECA6AA73022C2AE CRC64;
METAEQKELR RVAFFAIVVS TVAVIAAVVT LPMLYSYVAN FQSHLIIETD FCKTRARDMW
AEIHHIDGPE FTRAKRQYGS SPNPPLSAPV VGGYGQPPVV NNEPNPTCCP CQQGPAGPPG
PPGDDGEDGP DGLRGSDGNS GKDGSMLESA INNDACVICP PGPSGPQGMA GAKGPQGPKG
APGKNGDDGK PGLPGMQGPM GMMGMPGRQG VAGPKGAPGR IVQVNGPAGP AGHKGPRGPP
GPRGEAGLDG ASLEGPAGPP GLPGRPGPPG QPGPQGPEGA RGAPGEPGTC EHCPIPRTPP
GY
//
