ID W2SLH6_NECAM Unreviewed; 355 AA.
AC W2SLH6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Zinc carboxypeptidase {ECO:0000313|EMBL:ETN70524.1};
DE Flags: Fragment;
GN ORFNames=NECAME_14726 {ECO:0000313|EMBL:ETN70524.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN70524.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M14 family.
CC {ECO:0000256|ARBA:ARBA00005988}.
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DR EMBL; KI668942; ETN70524.1; -; Genomic_DNA.
DR RefSeq; XP_013292751.1; XM_013437297.1.
DR AlphaFoldDB; W2SLH6; -.
DR EnsemblMetazoa; NECAME_14726; NECAME_14726; NECAME_14726.
DR GeneID; 25354753; -.
DR KEGG; nai:NECAME_14726; -.
DR CTD; 25354753; -.
DR OMA; WGYRWGE; -.
DR OrthoDB; 3540647at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.340; Metallocarboxypeptidase-like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 2.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR036990; M14A-like_propep.
DR InterPro; IPR003146; M14A_act_pep.
DR InterPro; IPR000834; Peptidase_M14.
DR PANTHER; PTHR11705:SF139; PEPTIDASE_M14 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11705; PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B; 1.
DR Pfam; PF00246; Peptidase_M14; 2.
DR Pfam; PF02244; Propep_M14; 1.
DR SMART; SM00631; Zn_pept; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645,
KW ECO:0000313|EMBL:ETN70524.1};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 66..101
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETN70524.1"
SQ SEQUENCE 355 AA; 40890 MW; 4951F47228818C29 CRC64;
VTEKPRILID VWGEPSRQNP VADVLVAPEF LGAFLEMLSR KGVTYVETIK EDIGREIRRE
RRHLQRYRSR AKRSFDAMDF DVDNYHSYDE MVEFMQLLAA QRPDLVTLLN VSRTFEGRPM
YGVKLVSEYG KDPVITRSVD KFDWYIIPQA NPDGYEYSRV SDRLWRKTRS RNITVNKWCI
GADANRNWGH RWGLRDLVTW QIPNLIIYAS LHSYGQLLLS PWGYTQARPD NYLDQVAEKN
SRNAAKIAVA AMRNATGAEY NYGTIAELMC KWALLIGSLI FARISAIADP ASGTSIDYMQ
DRGVPYIFGV ELRPLDSHDS YAFSLPPHYI RPTGNLRKCL YFDANSADSM YFVLL
//
