ID W2SMH6_NECAM Unreviewed; 334 AA.
AC W2SMH6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Organic solute transporter alpha-like protein C18A3.4 family protein {ECO:0000313|EMBL:ETN70825.1};
GN ORFNames=NECAME_14517 {ECO:0000313|EMBL:ETN70825.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN70825.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KI668891; ETN70825.1; -; Genomic_DNA.
DR RefSeq; XP_013293052.1; XM_013437598.1.
DR AlphaFoldDB; W2SMH6; -.
DR STRING; 51031.W2SMH6; -.
DR EnsemblMetazoa; NECAME_14517; NECAME_14517; NECAME_14517.
DR GeneID; 25354544; -.
DR KEGG; nai:NECAME_14517; -.
DR CTD; 25354544; -.
DR OMA; CLPMVIP; -.
DR OrthoDB; 2877401at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR005178; Ostalpha/TMEM184C.
DR PANTHER; PTHR23423:SF76; ORGANIC SOLUTE TRANSPORTER ALPHA-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR23423; ORGANIC SOLUTE TRANSPORTER-RELATED; 1.
DR Pfam; PF03619; Solute_trans_a; 1.
DR SMART; SM01417; Solute_trans_a; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 313..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 334 AA; 37884 MW; 154EFE5B70A0081A CRC64;
MTLFDTLVKL LTDSLLNCTN SAEIPHASDY LSQLPTSFVI ALILATIICL ATASLGVLHI
LYISVYITQS DRRLFILFLA STAPFVSMLS LVAMYMPRVW FLSHLISFLY FSVALWIIIC
LLMQIFEGHH ALVSKMSEHL QHIEVATPPF CCVFPCLPKI QLESRKVRIC ELMVLQAPCV
RLFATLASLM IYFEYQDKGL IPLKVLDFIT LPSLLAGIYG THILVTTVSR LDELISYRYI
VVFRILDLFF MFFGLQQPVF DFLARYGAFG CGTVLPAIET SFFWKNFFTV VESFFVTLIS
TILLQPSKSS FFDKHPSCRS ITSSRNSHTN ETPT
//
