ID W2SND5_NECAM Unreviewed; 431 AA.
AC W2SND5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Phosphate transporter {ECO:0000256|RuleBase:RU363058};
GN ORFNames=NECAME_14924 {ECO:0000313|EMBL:ETN70212.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN70212.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- FUNCTION: Sodium-phosphate symporter. {ECO:0000256|RuleBase:RU363058}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in);
CC Xref=Rhea:RHEA:71259, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474;
CC Evidence={ECO:0000256|ARBA:ARBA00035083};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363058}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363058}.
CC -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC 2.A.20) family. {ECO:0000256|ARBA:ARBA00009916,
CC ECO:0000256|RuleBase:RU363058}.
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DR EMBL; KI668996; ETN70212.1; -; Genomic_DNA.
DR RefSeq; XP_013292439.1; XM_013436985.1.
DR AlphaFoldDB; W2SND5; -.
DR EnsemblMetazoa; NECAME_14924; NECAME_14924; NECAME_14924.
DR GeneID; 25354951; -.
DR KEGG; nai:NECAME_14924; -.
DR CTD; 25354951; -.
DR OMA; MSGILFY; -.
DR OrthoDB; 5488632at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR001204; Phos_transporter.
DR PANTHER; PTHR11101; PHOSPHATE TRANSPORTER; 1.
DR PANTHER; PTHR11101:SF80; SODIUM-DEPENDENT PHOSPHATE TRANSPORTER 2; 1.
DR Pfam; PF01384; PHO4; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363058};
KW Phosphate transport {ECO:0000256|ARBA:ARBA00022592,
KW ECO:0000256|RuleBase:RU363058};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363058};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363058};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363058}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 93..114
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 120..138
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 150..171
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 316..333
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 354..372
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 406..430
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
SQ SEQUENCE 431 AA; 45807 MW; BA32875985CAC5EA CRC64;
MIEDLAAFQS ALMPWLVVGA IIAFILAFAI GANDTANSFG TSVGSKVVTL TQAYILASVF
ETLGACLLGH KVTDTMRKGV LDLAVYNNSE LELMYGQISI LSGCGAWMLL ATFFKLPVST
THSIVGATIG FSLVLKVLYF DRLTLEQCAI VSIIFGLVSA VAAKFIVAPW LKRNILARSD
VESNNSSELN ALAGQKAVLL EYENERTRGD GKSNGSGRDS QGKDQSAIEA IADWRTKQSL
AMNTVAPSSS VASFFRSSKP EDPQAAHLFS LLQVMTACFG GFAHGGNDVS NAIAPLVSLY
VIYKEGSTAQ TLPTPGYILL YGAVGMCIGL WMLGHRVIYT VGENLTKITP PSGFAIEFGA
AVTVLIASKL GLPISSTQCK VGSVVAVGLI QANHSVRWLT FRNISLSWIV TLPVAGLLSA
GVMCLFRAFV L
//
