ID   W2SQ46_NECAM            Unreviewed;       535 AA.
AC   W2SQ46;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE            EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN   ORFNames=NECAME_14104 {ECO:0000313|EMBL:ETN71745.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC   Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN71745.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
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DR   EMBL; KI667004; ETN71745.1; -; Genomic_DNA.
DR   RefSeq; XP_013293972.1; XM_013438518.1.
DR   AlphaFoldDB; W2SQ46; -.
DR   STRING; 51031.W2SQ46; -.
DR   EnsemblMetazoa; NECAME_14104; NECAME_14104; NECAME_14104.
DR   GeneID; 25354131; -.
DR   KEGG; nai:NECAME_14104; -.
DR   CTD; 25354131; -.
DR   OMA; CEIDIHR; -.
DR   OrthoDB; 2911650at2759; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 2.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   PANTHER; PTHR46257; TYROSINE-PROTEIN PHOSPHATASE CORKSCREW; 1.
DR   PANTHER; PTHR46257:SF3; TYROSINE-PROTEIN PHOSPHATASE CORKSCREW; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF55550; SH2 domain; 2.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT   DOMAIN          89..186
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          215..490
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          404..481
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   REGION          500..535
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   535 AA;  61007 MW;  6DF4652E4EF05426 CRC64;
     MLILVVGRET SDRGKAITHV KIQKNSDDFL DLFGGESFAS LSELVQFYID NPEQLQERNG
     ESIIMKRPVS IPLYEPAAQE ARAPASQRWF HANITGTEAV DLLSKEKQWT YLVRESQRAP
     GSYAITVKTT DDHVVHILIQ KKADTGMYHV GGGDEFRTVS ELLAHYNNNP MVEEGSQRVV
     HLMNLVPSTC VPADAIDERI RLLEEIDPVT KKSGFLEEFE RIQQVDDQFS SRREGKKEQN
     ISRNRYKNIV PFDHTRVVLK DVPANESDYI NASYIRIPKG PPLHLFANRE YISTQGCLPN
     TLLDFWRMVW QENSRVIVMT TKEMERSKSK CHVYWPALRE ELNLREYVIK TVEETKVPGD
     NGLDMFIKRR FMVAKKGMPQ REVFHLQFTG WPDHGCPEQP ESVLQFLDAV DTACKKAIST
     QGPVIVHCSA GIGRTGTFIV IDILLNQIRH RGSSCPIDIP RTVMKIREQR SRMVQTEAQY
     VFLYRAISCY IGMISRSRHP SDDVGDSGQP LHLPPPPLPR RRPVPDVAQA YVNNG
//