ID W2SR70_NECAM Unreviewed; 904 AA.
AC W2SR70;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Helix-loop-helix DNA-binding domain protein {ECO:0000313|EMBL:ETN71336.1};
GN ORFNames=NECAME_14255 {ECO:0000313|EMBL:ETN71336.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN71336.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KI668732; ETN71336.1; -; Genomic_DNA.
DR RefSeq; XP_013293563.1; XM_013438109.1.
DR AlphaFoldDB; W2SR70; -.
DR STRING; 51031.W2SR70; -.
DR EnsemblMetazoa; NECAME_14255; NECAME_14255; NECAME_14255.
DR GeneID; 25354282; -.
DR KEGG; nai:NECAME_14255; -.
DR CTD; 25354282; -.
DR OMA; CARKICI; -.
DR OrthoDB; 3668492at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd11394; bHLHzip_SREBP; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR46062:SF1; LP12374P; 1.
DR PANTHER; PTHR46062; STEROL REGULATORY ELEMENT-BINDING PROTEIN; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000313|EMBL:ETN71336.1};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 343..393
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 248..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 383..410
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 331..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 904 AA; 100583 MW; 5377DC958254C264 CRC64;
MLTTSSNMFN CNDIPMSDPF LSLETNLEDI SDVIRMDTED VLAMDATWGG GHQQPHASHY
PYAKPFVRPN QHSPPQDYYD SNRSREIGSI VSLLQADSPP SSDPYAAMKF SPPNFDTNVN
LNGPAGMLPK LGASVVQPLQ INHYQSGDQR LFALENDKEL GSRAGLWFPS AETVFPGLQA
QQLTAPAMQP FSQVLSPPAM FIDTKPPFVQ NSPEQNYMVS PGGGYSSCTS VAATANVKVE
SPVSIQMTRS HSDGNTADML SPQQNSSNGA TTKEELLRLL VNMSPGQVER LKGSAGRRSS
SHSRPSGVAT RVPRDDSWPQ DDDSDDEDEV TSEEPRRKGP KTERRTAHNL IEKKYRCSIN
DRIQHLKAIL AGDDAKLSKS ATLRKAIEHI GKLEAENRDL RQEVQRLSSI LHNNNIEVLP
PSVPVVGSPA LSPSTSSASM QSPGATTSPT TSPTLPPKGA KRPRTSVEQG RVTIFAIMFA
MLMWNPLNLL ATGSSVSARS NHDNVAPTGG RVLSENTDAF DNYLTADEWW QTRVIKPCFV
WSVNIFVVVC VLTRLLVYGE PVQDFKSRSW RVFLSTQARA RHEAEHGNVR EAQRQYIECL
QILERPLPSA GVEQALSVVW QIIRHALNSL WIGRPTFSFT PFLQNLGCKR IKFISQELYS
LTENLRSHRK RGDVLSRLRA GLKLRLLTLL ASELSGDNGL KEIDTVDVSR LLITISMAGG
LPKKENSWDC ATWLTEGDAL CTWWTHVFTC ALFWKQGMRE KAKQHYAVVR RCPDELLNSP
LALAVGHAFC SKKLCADDRD SANFGKFVLI HSRKALEQLR LAYTREAAPE VAHLQDALRR
LAYEWVMSSL LDAWRQNLES GKPYWCQHIT EDYRTLYQEA CNHYTHIQLH GGGERGSRVG
SSSL
//
