ID W2STE2_NECAM Unreviewed; 706 AA.
AC W2STE2;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=phospholipase D {ECO:0000256|ARBA:ARBA00012027};
DE EC=3.1.4.4 {ECO:0000256|ARBA:ARBA00012027};
DE Flags: Fragment;
GN ORFNames=NECAME_13698 {ECO:0000313|EMBL:ETN72890.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN72890.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:14445,
CC ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58608; EC=3.1.4.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000798};
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DR EMBL; KI662648; ETN72890.1; -; Genomic_DNA.
DR RefSeq; XP_013295117.1; XM_013439663.1.
DR AlphaFoldDB; W2STE2; -.
DR STRING; 51031.W2STE2; -.
DR EnsemblMetazoa; NECAME_13698; NECAME_13698; NECAME_13698.
DR GeneID; 25353726; -.
DR KEGG; nai:NECAME_13698; -.
DR CTD; 25353726; -.
DR OrthoDB; 335467at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0070290; F:N-acylphosphatidylethanolamine-specific phospholipase D activity; IEA:UniProtKB-EC.
DR GO; GO:0004630; F:phospholipase D activity; IEA:UniProtKB-EC.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd01254; PH_PLD; 1.
DR CDD; cd09138; PLDc_vPLD1_2_yPLD_like_1; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR InterPro; IPR015679; PLipase_D_fam.
DR PANTHER; PTHR18896:SF76; PHOSPHOLIPASE; 1.
DR PANTHER; PTHR18896; PHOSPHOLIPASE D; 1.
DR Pfam; PF00614; PLDc; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00155; PLDc; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT DOMAIN 259..286
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT REGION 333..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETN72890.1"
SQ SEQUENCE 706 AA; 80575 MW; E36CE27B4065864A CRC64;
AEFLEVSRFS FVNELGGKHT EGFVKKRPGG SRVFLGWKQC CVRYMLPWSK RWLMVRDSFV
AYMDHRTEQI RLVLLMDRDF KVAAGGKEAD GIPTGLIITN SQHELHLKCR RIQDTARWKA
IIEQAMHGIG SIWIQPHRFS SSFPVRENCY GKWFVDARTY MSQAADMMEL AREEIFIAGW
WISPEIYMKR PALEGNYWRF DEILKRKANQ GIRIFILMYK EMEMALGLNS MYSKRTLQAL
HPNVKVMRHP DHYPSTGTFF WAHHEKLVIV DQLIAFVGGV DLCFGRWDDN HHLLTDLGSV
QFGQQHLVLQ DMSMATGLRA LVKAPLTLSP LGLEEDENVE SSETKESVEV PRDEEKKEHH
QVTKIAIGGV EEVNYSDFLD SAGSDGEVVY ADADTGGVML KVFKKGTRSV SADSARKSPV
GEQPQPSPSP SPIPTTTASK LAAVSGKKPT LLNVVEDAKG KKHVRRAASA ATKSRVPLDM
LDKAGPAPSM FEKATKMGMD FQTAAEKYKE YVESGAVQKE KHRSQTPPMK RKESRLSRAV
GNWRSNRAKR KWKQVLDSDE VMAGYELDFL RLKQMDTDDK DSIDGGVKLW VGKDYVNYIH
KDFVEVDLPF HDFIDRGSTP RMPWHDIHSV TFGASARDVA RHFIQRWNAT KTEKLKDDVN
YPYLLPKSHE NLKVPRVFRN PNFSYNVNIQ QPTLYLFQMN LNIISD
//
