ID W2STH3_NECAM Unreviewed; 1063 AA.
AC W2STH3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Cullin family protein {ECO:0000313|EMBL:ETN72002.1};
GN ORFNames=NECAME_14015 {ECO:0000313|EMBL:ETN72002.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN72002.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; KI665955; ETN72002.1; -; Genomic_DNA.
DR RefSeq; XP_013294229.1; XM_013438775.1.
DR AlphaFoldDB; W2STH3; -.
DR STRING; 51031.W2STH3; -.
DR EnsemblMetazoa; NECAME_14015; NECAME_14015; NECAME_14015.
DR GeneID; 25354042; -.
DR KEGG; nai:NECAME_14015; -.
DR CTD; 25354042; -.
DR OMA; KQLIMDP; -.
DR OrthoDB; 21270at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR012479; SAP30BP.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF168; CULLIN-3; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR Pfam; PF07818; HCNGP; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 692..931
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 1..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1063 AA; 122501 MW; 8697E176CB0ED1DF CRC64;
MNTLADYGDE SDEESPRRRS FVVEREPAEV ASSTNSQHNS THSSPHHKSP DVSPRPRRDS
DMMFDDGDMM FDEPRRYSSF SDHSDHSDTA EFREPPPPKR KVDHSPSPSL PTPTSKIPQV
SSAVSLVSYS GAEDEKEDAF ERADRAAENV SRPASPPSGM VEPRPPERVS QDSETDDENE
RLIDMALEDG RNAMKQIEDG GSTGSGGWTP RPYDSPLHGV DHEIDSKRVD TPPHQEVNIP
PAPTTECDPE LVLLAFKEIF YKHFERKAAG IDVNVSVQAR KDFQNPSSYE QLILNFGIDE
VGYNYPRLSS MSGTRPQTSG SSSRMRIRSF PAAMDEKYVT QVWEMLKKAI QEIQRKNNSG
LSFEELYRNA YTMVLHKYGE RLYTGLKQVV EDHLRNYVRV KIVESLDSGN FLEVMNEAWN
DHTTAMVMIR DILMYMDRVY VEQNKVEQVF HLGLAIFRDH VLYQDFIHLH LRTTILSLIQ
QERRGAVVNW TGIKSACQML VALGIHSHDV YVDEFETPFL VSTAEYYRCL SMCFLVSNSA
SLYVKKVEQC IREESERAKR YLDPQTESKV LDVLENVLIK DHMHTIVNME HSGVHVMLSN
DKFDQLASLY GLLQRVENGL NVMADAMSKY LRQTGAATVR EDCERTPVVF VEDLLELKER
FDEFLLMSFQ RDKMFKNRIQ TEFETFINLN KNSPEYLSLY MDEKLRKGLK SENDENAEKL
LDKSMVLFRF LQEKDVFEKY YKQHMAKRLL LDKSISDDME RMMISKLKTE CGCHFTLKLE
NMFRDKELWA TQATDFKEYR ENFLRGGNLM EISVRVLTAG IWPTQSVPVC ILPSACEHAF
NVFTNFYISK HNGRKLTLNT MLGTADVKAV FYGGTAAAAR KKEENKILMV NTHQMVILMC
FNSQPRLTFQ ALLEQTSIAE RELKRNLQSL AMGKPTQRVL CRKGKGKDID ATDEFSVNDN
FQSKLTRIKV QLVTFKGETE PEKKETRSKV EDDRKHEIEA AIVRVMKSRK VLDHNNLITE
VTQQLRHRFL PNPILIKKRI ESLIEREYLA RDTQDLKLYN YVA
//
