ID W2SVB5_NECAM Unreviewed; 436 AA.
AC W2SVB5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=HORMA domain protein {ECO:0000313|EMBL:ETN73689.1};
GN ORFNames=NECAME_00778 {ECO:0000313|EMBL:ETN73689.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN73689.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KI660422; ETN73689.1; -; Genomic_DNA.
DR RefSeq; XP_013295916.1; XM_013440462.1.
DR AlphaFoldDB; W2SVB5; -.
DR STRING; 51031.W2SVB5; -.
DR EnsemblMetazoa; NECAME_00778; NECAME_00778; NECAME_00778.
DR GeneID; 25340822; -.
DR KEGG; nai:NECAME_00778; -.
DR CTD; 25340822; -.
DR OMA; KSSNFMT; -.
DR OrthoDB; 2915579at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR Gene3D; 3.30.900.10; HORMA domain; 1.
DR InterPro; IPR003511; HORMA_dom.
DR InterPro; IPR036570; HORMA_dom_sf.
DR PANTHER; PTHR48225; HORMA DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR48225:SF7; MEIOSIS-SPECIFIC PROTEIN HOP1; 1.
DR Pfam; PF02301; HORMA; 1.
DR SUPFAM; SSF56019; The spindle assembly checkpoint protein mad2; 1.
DR PROSITE; PS50815; HORMA; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT DOMAIN 32..236
FT /note="HORMA"
FT /evidence="ECO:0000259|PROSITE:PS50815"
FT REGION 305..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 436 AA; 48565 MW; D716C4DB45FFD2ED CRC64;
MALLLSPKCV EEKPDVSKRW AGTFPEEVSR LHDSTIFITR CMYITFSHIL ASRRLLPKNV
FKTRVIDGDL KACVMDTSDV LGARLVQKFK GINHAVELRY LRELMLVVSA TEEDEKDAIE
MYTWRLRYDT DGNPEAELRQ ADGTVMASLR FRGMKYLKKQ VTELLVMIRT LCRGTLSPLP
SGVSGTLRIT YTDRAPRGYQ APGFYRSPED PVLRSEAQEV EIGSLQTKHH GASVVVQSIF
IDDAYAVGLR LKETMKITSL DDSLNESLGE EHGAGDEDNR SSIDDTMERI SDGIAQQINV
VEIPRSEEVL APDGPRTILR SDQSDSSNSS RTSLVEVRGS TIHMNESDTS PEDAPPKRPR
RGRNAAAKVQ PGKPIAERAK SPILVSAAPQ IETTTTTPSS RKYANDSHDT PPAKRTPGEI
KCSKFTPKEP PTRRRK
//
