ID W2SZA0_NECAM Unreviewed; 112 AA.
AC W2SZA0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Transcription initiation factor IIF subunit alpha {ECO:0000256|RuleBase:RU366044};
GN ORFNames=NECAME_12608 {ECO:0000313|EMBL:ETN74938.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN74938.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- FUNCTION: TFIIF is a general transcription initiation factor that binds
CC to RNA polymerase II and helps to recruit it to the initiation complex
CC in collaboration with TFIIB. It promotes transcription elongation.
CC {ECO:0000256|RuleBase:RU366044}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU366044}.
CC -!- SIMILARITY: Belongs to the TFIIF alpha subunit family.
CC {ECO:0000256|RuleBase:RU366044}.
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DR EMBL; KI660324; ETN74938.1; -; Genomic_DNA.
DR RefSeq; XP_013297165.1; XM_013441711.1.
DR AlphaFoldDB; W2SZA0; -.
DR STRING; 51031.W2SZA0; -.
DR EnsemblMetazoa; NECAME_12608; NECAME_12608; NECAME_12608.
DR GeneID; 25352636; -.
DR KEGG; nai:NECAME_12608; -.
DR CTD; 25352636; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032968; P:positive regulation of transcription elongation by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR InterPro; IPR008851; TFIIF-alpha.
DR Pfam; PF05793; TFIIF_alpha; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|RuleBase:RU366044};
KW Nucleus {ECO:0000256|RuleBase:RU366044};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transcription {ECO:0000256|RuleBase:RU366044};
KW Transcription regulation {ECO:0000256|RuleBase:RU366044}.
FT REGION 14..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 112 AA; 12602 MW; CB8899EDD389050D CRC64;
MNQFALKAQI MSQLKAGEED GEQLEKPTRS LKIKDGYSSS DSDGEDDDRN DEDATPKKKE
GVQKKKKAHE KPKKNKRPHV ENGDEVAKYE SSDGEDEGRE YDYMSDSGSD SE
//
