ID W2SZN6_NECAM Unreviewed; 438 AA.
AC W2SZN6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Fibronectin type III domain protein {ECO:0000313|EMBL:ETN74187.1};
GN ORFNames=NECAME_13150 {ECO:0000313|EMBL:ETN74187.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN74187.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI660380; ETN74187.1; -; Genomic_DNA.
DR RefSeq; XP_013296414.1; XM_013440960.1.
DR AlphaFoldDB; W2SZN6; -.
DR STRING; 51031.W2SZN6; -.
DR EnsemblMetazoa; NECAME_13150; NECAME_13150; NECAME_13150.
DR GeneID; 25353178; -.
DR KEGG; nai:NECAME_13150; -.
DR CTD; 25353178; -.
DR OMA; HCRTENG; -.
DR OrthoDB; 2912783at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR44170:SF30; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 2.
DR SMART; SM00060; FN3; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR PROSITE; PS50853; FN3; 4.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..91
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 96..199
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 204..326
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 330..433
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 78..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 438 AA; 49023 MW; F3D1A2B888459C8A CRC64;
MEPADTVSPV KEFWVQYQMD SETEGTQWRT HPVPVQAHPN DRIEGDQRMV SGKATVALQP
FGHYVFRVLA RNGVGDSSPT RVKDVCITPP KQPDRNPAGV WAKGASPENI VVHWRPMARE
EWNGKNFHYK IKYRPSEGGD GEWKEVQVND PFADRYTITL DDDKDAKPFQ PYEVQVQAVN
DEGQANIVPE TIQGYTGEGV PSSIPGGFRV VSKDGTTATF AWNPVDPKSA NGNFTGYKIT
YWYDEAEGEE ETSDVETKFR FKRSDRAVNK RDVESRRRTI VFGPKATTGT VTDLKPDTVN
YATIQVTNSA HEGEPSEVIQ FRTAEGVPSP VRGLRAHPMN PRDTEEKAIV HLIWRRPRRP
NGKLLKYVIE HCRTENGRVV EKDCPKQDVD ADQTQIRLSG LEFETPYRFI VRAQTSAGEG
DPNSADATTL PEVVAAGG
//
