ID W2SZX7_NECAM Unreviewed; 746 AA.
AC W2SZX7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Patched family protein {ECO:0000313|EMBL:ETN75295.1};
GN ORFNames=NECAME_12503 {ECO:0000313|EMBL:ETN75295.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN75295.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; KI660310; ETN75295.1; -; Genomic_DNA.
DR RefSeq; XP_013297522.1; XM_013442068.1.
DR AlphaFoldDB; W2SZX7; -.
DR EnsemblMetazoa; NECAME_12503; NECAME_12503; NECAME_12503.
DR GeneID; 25352531; -.
DR KEGG; nai:NECAME_12503; -.
DR CTD; 25352531; -.
DR OMA; FTGTHWF; -.
DR OrthoDB; 2880705at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR PANTHER; PTHR10796:SF189; SSD DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 664..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 689..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 215..373
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 746 AA; 83711 MW; FF7AE4FE82943870 CRC64;
MSLSTTCGRL GTVVGTRPLM FFLASIALFF ISVLLLGAIP PEIRLSFDDG YTTSGAPSKR
ELQTQMEYFG AKGKPWYMAL FAEPRDQENG SMTESKEYDE FKSFYKRIKT NIVIRQDGNR
SITYMDYCGS TCDVNDQIFK THGKDIVKSR LTALYFMAFP NNTQASDDLR HFEAIVSDQV
TRHNADMTKV TTITQHGARG MQMEIARGMK FVLGKLIGGV FLAGIVTLIC FVILNRIHGR
SNGRVLLLSF GAMFLPLMSL ISAAAFCSFI GIHTNTISVV APALTFALGI DGMLILYNSW
ISSHKTINVK DRMSEVFASC FPSITIVSSA AIGLVVGGLF PIEEYAILSF YMGITIVFVY
AYQMCFFPAL MLWCSSVDTH SPLTQEQSKP TKLAKRPWSV RQMPFEFTLA QNFHRVVVLS
GPSPSYIPWV IKDSLGFVGI QVWFEFFNVL YFIKKPPRFD DPSSYRRFKN MISEIESLPG
NINKSAMMWI NDFERHTGMT GNESALNMEL FKEFITHEIY KAWNSGVRYR YEGDVPIITQ
MLYIGAYEGV KTMRDKANLL SQCRRVVANY PEFDVVPFDT DVGMVDVILQ ISYVAYLIPL
SILIGISVVA MVFVGNLTLS SIVVISSILI FLGAKLALLF TILTLEHDQI NDDVQRLTLT
FRRMLYPAAM SAIAGSMVFF PMILTNVVIF RWLAVINLFI LVAGVTHTVL VTPLILISLP
SKLAGTWFFC TQNQKNDHVA MKSLST
//