ID W2T2G0_NECAM Unreviewed; 1292 AA.
AC W2T2G0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Putative septum site-determining protein MinC {ECO:0000313|EMBL:ETN76088.1};
GN ORFNames=NECAME_11934 {ECO:0000313|EMBL:ETN76088.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN76088.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI660251; ETN76088.1; -; Genomic_DNA.
DR RefSeq; XP_013298315.1; XM_013442861.1.
DR STRING; 51031.W2T2G0; -.
DR EnsemblMetazoa; NECAME_11934; NECAME_11934; NECAME_11934.
DR GeneID; 25351962; -.
DR KEGG; nai:NECAME_11934; -.
DR CTD; 25351962; -.
DR OMA; TGHDYLK; -.
DR OrthoDB; 5474354at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011646; KAP_P-loop.
DR PANTHER; PTHR24116; KINASE D-INTERACTING SUBSTRATE OF 220 KDA; 1.
DR PANTHER; PTHR24116:SF0; KINASE D-INTERACTING SUBSTRATE OF 220 KDA; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF07693; KAP_NTPase; 1.
DR SMART; SM00248; ANK; 11.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 7.
DR PROSITE; PS50088; ANK_REPEAT; 9.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 570..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 74..106
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 107..139
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 141..173
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 174..206
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 207..239
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 240..272
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 273..305
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 306..338
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 339..371
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 498..848
FT /note="KAP NTPase"
FT /evidence="ECO:0000259|Pfam:PF07693"
FT REGION 1082..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1171..1205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1292 AA; 142953 MW; 59FAB61DD9270409 CRC64;
MVQAGGHRRP WAEAASSAFA VASALPSSMN SEQIADLFEK TGETFLIAAA RTNNVHAVKN
LAADPDLLDE TDNEGWSALL NASHKGHVDV VRILLEAGAS VDLPDMMGWS PLMWAVYKCH
PEIVDMLLNY GAHVNLIDEE DGLTPLIVAS GRGFTSVVEK LLAADAQVNA CDKFGSTALI
WAARKGHLPI VQMLLNAGAE VDAVGMGSST ALMLATKGNY LTVVDLLLTR EPNVNVVDQN
GLSALGIAAR EGYADICESL INSGAFVNQS DKYGNWILIS AVRSGNANIV RLLLEKFADV
NARDSENRTA LHLAIDKSFM DIVYIILERK PNLELKNRDG ETPLLRAVKS RHVALCDLLV
KSGAKISAAD NNGDNALHLA LRARSRRLTQ TLLANPSDSR LLYRPNRLGQ TPYSIDNANP
QPILPLIFGP IDAEQHMDTM LGYDVYSNVL ADIGFLYYGS EMRGWSAPGR VANSLSRFIY
RIRLLWNVAT LYAPMHSEND IASNPVSFLF ADYHRLSSIG GEQALAKIVA TLFESAETHF
GVLPVRLFCS LRTAYPGQYG SLRRHCGVPV VLLVGVAVCM LLSAEVFMII WLFSDRDTSS
GALLVASIAF MVVFLMLTIY PIIILLRYGY TNVPRKHVNE AARSVHKLRF EGLMQKLQTE
VDILADMIRS LDAFTRSQTR LVVVVDGLDN CEQERMVQTL DALELLFSAR KHRPFITIIA
VDPHIIVSAI NHNMHSALTG TELTGHDYLK NIVNMPLYLH NSALRQLQNK LKDKRESLAD
WKERYRRQDT FHGSHLSLAD GRQSRKATIV VGTRSIGESL LSDDYFSNMN PRAMRRIVNA
LTLTGRLMRA FEIDFSWLSL GHWVSLLEQW PSRMCWLIDR AVDINNNGLT LAEVYHQLKD
HIPKKDSLIE LDRNPDNFEA FLDSPTIPSA EQLTVGHVKK FVPCTSNLDP YLRKLIRERR
QGLEDPVQEL GFGSVVIPPN AKYLFGDEKV WSTVCTPLVE MRLDDVCALL KKLDIASNRL
DAIVRKFEQL NLGGLVLASC SLQDLKDALG IPLGDWTMVR LLVETLKAFG SNVPGVKTDK
RRALTLPEED EEGSEESVDL TTRRGTIVQS PSAMITAEER RRSMAMPEEI NTDHKWLMES
LSGMDLTQPE GDLNLAPSSA ASVRFDDAAE DGLASDADST ESRFGSRENL LDPGPILSRH
SSSTGRGDLM RQIHNDSIHS TEGVISARSS VVSDDDHQVT IMRRDGSIVS GERPQLTNIF
GRENGNARRI KCGHSAMMPI NAVATLYWSV SE
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