ID W2T2W1_NECAM Unreviewed; 471 AA.
AC W2T2W1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=WD domain, G-beta repeat protein {ECO:0000313|EMBL:ETN75297.1};
GN ORFNames=NECAME_12487 {ECO:0000313|EMBL:ETN75297.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN75297.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI660309; ETN75297.1; -; Genomic_DNA.
DR RefSeq; XP_013297524.1; XM_013442070.1.
DR AlphaFoldDB; W2T2W1; -.
DR STRING; 51031.W2T2W1; -.
DR EnsemblMetazoa; NECAME_12487; NECAME_12487; NECAME_12487.
DR GeneID; 25352515; -.
DR KEGG; nai:NECAME_12487; -.
DR CTD; 25352515; -.
DR OMA; DYEDDIM; -.
DR OrthoDB; 3686044at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR037850; RBBP5/Swd1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44040; RETINOBLASTOMA-BINDING PROTEIN 5; 1.
DR PANTHER; PTHR44040:SF1; RETINOBLASTOMA-BINDING PROTEIN 5; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 65..106
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 352..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..369
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 471 AA; 52457 MW; D12367715B330093 CRC64;
MMNAELLERN FGVQFPEELD GTLDLQNGAA NCCKFNRWGT LVAVGSTDGR IFIFDFVTKG
IVKTWTAHAL PVSSLSWSRN GRRLLTASAD TTVAVWNVIE GACLHRLKYS AMVTSAVFNP
RNDNQVLVLQ LNYPPCLDEL EPRSQRVITN DIPGAVEDGV SAIAFDRRAK YLITGTNKGK
LVVYDAKTLK MVSWGRQNSV QQIKQIVVPR RGNFIITNSQ DRIIRTFDLD DILDCHNGST
IEPKHRVTDI VNKASWKAVC TDSEGYYICG ASTKAHSLYV WERTTGTLIK ILHGTKGECL
MDVQWHPIRP VILSVANGIV SVWTQAHVEN WSAFAPEFTE LEENAKYEEK EGEFDLEDED
AEVDDKANSQ DSDEEIIDVE SLKPNEILCS SDEEDNINAL LPDVTLKTGP LWFLPITPEC
DSSESLPLSG AHFADGRRAS SQILSVLEEE SRKRALPDSA AKAPMKGRKI K
//
