ID W2T2Z1_NECAM Unreviewed; 575 AA.
AC W2T2Z1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000259|PROSITE:PS50262};
GN ORFNames=NECAME_12033 {ECO:0000313|EMBL:ETN75934.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN75934.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; KI660263; ETN75934.1; -; Genomic_DNA.
DR RefSeq; XP_013298161.1; XM_013442707.1.
DR AlphaFoldDB; W2T2Z1; -.
DR STRING; 51031.W2T2Z1; -.
DR EnsemblMetazoa; NECAME_12033; NECAME_12033; NECAME_12033.
DR GeneID; 25352061; -.
DR KEGG; nai:NECAME_12033; -.
DR CTD; 25352061; -.
DR OMA; CIPPIAI; -.
DR OrthoDB; 4073525at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR InterPro; IPR019426; 7TM_GPCR_serpentine_rcpt_Srv.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24248:SF72; DOPAMINE_ECDYSTEROID RECEPTOR, ISOFORM A; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF10323; 7TM_GPCR_Srv; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 46..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 81..397
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 519..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 575 AA; 66724 MW; F4159CA1408FB4DD CRC64;
MLDPLLFENY NMSDACIEQT DTYRFLFQLR RLAEYAPQAR MLPTPLIVIC CIPVIIIILL
TVFGNLLVLF FKARVGPHRK WIFGRFLCRV WVAADVTFCT CSVVTICVIS VDRYLAVTRP
LRYKSLVTKT KVILVMIIIW TFSSSILLTT VRWEQPQCYD DVSISGFIVQ WRVPTFLRSL
SSQQFSRVFR RIVKIISTQR LHLGKKKEMK IIISLRAFFS ICFAGNEIRY LAHSVIFAFF
LPASVTLTLY WRIYKLARNR QRALDRGFLM ILGHNMNFLS NTISQQVMSI IIFYFSYFFQ
WISNCSCFAY LLQTQNTLRV HFGKNNGMVE HQRRVLRTHE RIAKTLGVVS CSFLFCWLPF
FSLYLTNYKC HGCISPIAID LASWLGYCNS MLNPIIYSFT VREFKRSALR LVFPTWQFAH
RCLPRLIPAP PDRMMQRMSR NGNRARNKTR HRSFEMDPNK AVMLTKRNCQ KRRQTEPAVF
GLQKKVCDAP VKMMIIEEDE DGGVHDDYTD TNGFSTYHET SRRLSDLPPP PSSRALLPID
ENESGTPSLN GECKTCPNDN SCSVKVFCDT KEADL
//
