ID W2T2Z9_NECAM Unreviewed; 525 AA.
AC W2T2Z9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=GCC2 and GCC3 {ECO:0000313|EMBL:ETN75616.1};
GN ORFNames=NECAME_12238 {ECO:0000313|EMBL:ETN75616.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN75616.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI660284; ETN75616.1; -; Genomic_DNA.
DR RefSeq; XP_013297843.1; XM_013442389.1.
DR AlphaFoldDB; W2T2Z9; -.
DR STRING; 51031.W2T2Z9; -.
DR EnsemblMetazoa; NECAME_12238; NECAME_12238; NECAME_12238.
DR GeneID; 25352266; -.
DR KEGG; nai:NECAME_12238; -.
DR CTD; 25352266; -.
DR OrthoDB; 2905240at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046:SF5; EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR Pfam; PF07699; Ephrin_rec_like; 2.
DR Pfam; PF02494; HYR; 1.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS50825; HYR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..50
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT REGION 482..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..525
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 57789 MW; 82DA5691A086DF17 CRC64;
MFVDNVGVVS IKSNYRSGQT FTWGYYRVVY VASDAAGNLA FCSFSVVVSP VECEIPKADI
QLQGNATFEN VNGTDAIMKA QVDCIDKYYP RADPEFYVCD IMIRQRLLDS LLNDLEPYCG
NCTGQFLTGY LLFSSTRDLL KNTISNSLEK EFPNSTLSIN EDISCDAKYP HFSRNEEIGS
CADCSAGHYW DEDHCVECPV DTYRGRNDPL EKCNKCPENT TTSGLIGQKN EDACHEICDT
GEYYDEWLKK CLPCPLGTYQ EKRGSVSCLP CAADTTTGFI GAKNATDCSF KCGAGQELDA
EGRCVPCARG TYWVSTNHFA GCVECPLGLT TVSTASKDIG GCEVVNCPVG THVNTNRPTP
VAPSTPFSSL CVTCEIGTYQ TTQLTPVQPA QPATTMQRHS SFRESMRARL REHHLPPPII
TSRVELDLLE QQARRQSIIM GVIPTPSRNL GSQIAVGYSP ESPGPSISAQ ITASKFTTQN
EVDQHPPLYE LPENASNSYS LHRAESSPYD ESNVFEEDDD EDYFG
//
