ID W2T475_NECAM Unreviewed; 457 AA.
AC W2T475;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=VMA21-like domain protein {ECO:0000313|EMBL:ETN76810.1};
GN ORFNames=NECAME_11421 {ECO:0000313|EMBL:ETN76810.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN76810.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI660206; ETN76810.1; -; Genomic_DNA.
DR RefSeq; XP_013299037.1; XM_013443583.1.
DR AlphaFoldDB; W2T475; -.
DR STRING; 51031.W2T475; -.
DR EnsemblMetazoa; NECAME_11421; NECAME_11421; NECAME_11421.
DR GeneID; 25351450; -.
DR KEGG; nai:NECAME_11421; -.
DR CTD; 25351450; -.
DR OMA; ETACHRT; -.
DR OrthoDB; 5397827at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IEA:InterPro.
DR Gene3D; 6.10.140.2220; -; 1.
DR InterPro; IPR007320; PDCD2_C.
DR InterPro; IPR019013; Vma21.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR12298; PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED; 1.
DR PANTHER; PTHR12298:SF4; PROGRAMMED CELL DEATH PROTEIN 2; 1.
DR Pfam; PF04194; PDCD2_C; 1.
DR Pfam; PF09446; VMA21; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 215..252
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
SQ SEQUENCE 457 AA; 52027 MW; 46B3E888CD571990 CRC64;
MDELIPNLRD ERVQGAVKSL LVYSIVILLV PLGSMFFLKR YLFEGLFGYS PNDSLTYSAV
IAVILVHIKV MQKYAHDLPV HLGFANRIET DELYRLRSIF LPLGKIGGKP SWLNPKILPG
TADLQCNVCQ KQMCFLIQVY ATSENDPPHS FHRTLFVFVC RNPLCSKSND ASNMVVFRCC
LPRLNPYYSF DGPMDPDLDG DVPDPRMTGD APQLCVICGC FASKKCGKCS TSWYCCRDHQ
ALDWTSGHKQ SCGNTDNPEG AKSLTNPLNK FLFKEYGIEM DQEYVPAELL ESLNDGDSED
DFDDKCADDD DESEDIKRKR MEEFEDFVAK NKLRNDQFKT DEMEAAVCDQ RSDFNFERFN
RLLNLNSEQV LRYQRSGTPL LATDRAPPPG EIPSCEICGA PRTFELQLMP HLLSLIDVDD
LRESIDWASV YIFTCSRSCE IENNGYAKEY VFKQDFS
//
