ID W2T4A1_NECAM Unreviewed; 325 AA.
AC W2T4A1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Kelch repeat protein {ECO:0000313|EMBL:ETN76071.1};
GN ORFNames=NECAME_11947 {ECO:0000313|EMBL:ETN76071.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN76071.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI660253; ETN76071.1; -; Genomic_DNA.
DR RefSeq; XP_013298298.1; XM_013442844.1.
DR AlphaFoldDB; W2T4A1; -.
DR STRING; 51031.W2T4A1; -.
DR EnsemblMetazoa; NECAME_11947; NECAME_11947; NECAME_11947.
DR GeneID; 25351975; -.
DR KEGG; nai:NECAME_11947; -.
DR CTD; 25351975; -.
DR OMA; CAICEAF; -.
DR OrthoDB; 5472491at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF475; RING CANAL KELCH PROTEIN; 1.
DR Pfam; PF07707; BACK; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00612; Kelch; 2.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 51..96
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 325 AA; 36125 MW; 16C987C9C5AD25B6 CRC64;
MSGWCAESDC PPRRSARSPE RDRTVHHFVN DRLSGEFFHN LTSLRRCDEL CDVVLEAYGP
SDAGGAESES APPTIIAAHK VVLAAACPYF RFLLEQLDAT NCLGIASFAQ THNCTQLAHA
AQMFTHQHFR MLIESEEMLT MDEASFTQLI SDDRLTTEGE EAVFEAVINW VKYDPSRKSS
LPNVLAAVRL PLISQEFLLD RAYQEPLIQE SPACIAMLCS VYHHILKKEV TPGLAASWVR
PRQPVPLSQV ELYDSRINRW RIADPLLEVR SGAGVAIYRD RVIAAGGHDG PLVRASVEML
GEDGWMHLPE MSVCRRNAGI VVANG
//
