ID W2T506_NECAM Unreviewed; 351 AA.
AC W2T506;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Type I phosphodiesterase / nucleotide pyrophosphatase {ECO:0000313|EMBL:ETN76052.1};
GN ORFNames=NECAME_11969 {ECO:0000313|EMBL:ETN76052.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN76052.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI660255; ETN76052.1; -; Genomic_DNA.
DR RefSeq; XP_013298279.1; XM_013442825.1.
DR AlphaFoldDB; W2T506; -.
DR STRING; 51031.W2T506; -.
DR EnsemblMetazoa; NECAME_11969; NECAME_11969; NECAME_11969.
DR GeneID; 25351997; -.
DR KEGG; nai:NECAME_11969; -.
DR CTD; 25351997; -.
DR OrthoDB; 1366859at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR CDD; cd16018; Enpp; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR10151:SF114; ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE C27A7.3; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..351
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004825202"
SQ SEQUENCE 351 AA; 39678 MW; 9106FC6DD6B701C1 CRC64;
MLAGIILSAI VAVRLGHMER QVQKAQVQLP QNVKEALDKL KLPTGWENYI PRPSAPPISP
DVPPIQAEVH EPEPEQQTQT YPQVKGCPGQ CKRKDFLKPP LVVLSLDGFA REYLDRFTVA
ALDYIAKCGA KAERVYPPFP SRTFPSHYTM VTGLYPESHG IVDNNIFDPN ISDKIESMKR
GDVDGYYQGD PIWNIYKRHG GKTACLYWVG CGFNISGLRP DISPPYNKDL PFRNRFEMIV
DWLLMPQESR PGLITAYLDQ PDTAGHYQLD DKDIESQIAI IDRNLRYLID TLDENGLLSC
INLVIVSDHE MMPYLQVFPD IAAASLLSGQ PRRSTMRSRE VVHLPVLSRH P
//
