ID W2T5N5_NECAM Unreviewed; 267 AA.
AC W2T5N5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=CUB domain protein {ECO:0000313|EMBL:ETN77218.1};
GN ORFNames=NECAME_11216 {ECO:0000313|EMBL:ETN77218.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN77218.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; KI660186; ETN77218.1; -; Genomic_DNA.
DR RefSeq; XP_013299445.1; XM_013443991.1.
DR AlphaFoldDB; W2T5N5; -.
DR EnsemblMetazoa; NECAME_11216; NECAME_11216; NECAME_11216.
DR GeneID; 25351245; -.
DR KEGG; nai:NECAME_11216; -.
DR CTD; 25351245; -.
DR OrthoDB; 2877914at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001506; Peptidase_M12A.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR Pfam; PF01400; Astacin; 1.
DR Pfam; PF00431; CUB; 1.
DR SMART; SM00042; CUB; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS51864; ASTACIN; 1.
DR PROSITE; PS01180; CUB; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT DOMAIN 1..51
FT /note="Peptidase M12A"
FT /evidence="ECO:0000259|PROSITE:PS51864"
FT DOMAIN 28..150
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
SQ SEQUENCE 267 AA; 30282 MW; 2A4AAE3ADA570A85 CRC64;
MHYGPFGFAS DPDKPTIRTL ERIQQSTIGQ RISPSFLDYQ AVSNKTRFIN SVNYPHGFKK
GVECFWLLRA PREGRVFLEF AEPFEFLCED TCDKSYVEVK YHSDKRLTGA RYCCSSPPKE
RFISLDNELV VIMREYVEGY RGFRAKFWSD VSEPILETTK YITSAIQTTP TSTRQATLPI
TTETPKTTED LLAIPKISFT DKTVEPTHRW SEKPFTLTST RRNTPKTGTK NVTVALGQNG
LENVHNHAVV AAIGFAQNNV IKPTAGR
//
