ID W2T883_NECAM Unreviewed; 267 AA.
AC W2T883;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
DE Flags: Fragment;
GN ORFNames=NECAME_10789 {ECO:0000313|EMBL:ETN77809.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN77809.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|ARBA:ARBA00010107}.
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DR EMBL; KI660150; ETN77809.1; -; Genomic_DNA.
DR RefSeq; XP_013300036.1; XM_013444582.1.
DR AlphaFoldDB; W2T883; -.
DR STRING; 51031.W2T883; -.
DR EnsemblMetazoa; NECAME_10789; NECAME_10789; NECAME_10789.
DR GeneID; 25350818; -.
DR KEGG; nai:NECAME_10789; -.
DR CTD; 25350818; -.
DR OrthoDB; 118560at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF210; HISTONE ACETYLTRANSFERASE KAT7; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..222
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT ACT_SITE 120
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETN77809.1"
FT NON_TER 267
FT /evidence="ECO:0000313|EMBL:ETN77809.1"
SQ SEQUENCE 267 AA; 30679 MW; B8BCEBD9BA9F7473 CRC64;
EWRHPPGNEI YRHNNVSVFE VDGNVSRIYC QNLCLIAKLF LDHKTLYYDV EPFLFYVVTK
NDDYGFHFVG YFSKEKYSQQ KFNLSCIVTL PCYQKQGFGR FLIDFSFLLS RKEHLSGTPE
RPLSDLGRIS YASYWRTSIF EYIHEHVPKN STKKLLLTDL AKGTGIAVHD IVEVFDALKW
FQKQNGSLVL VFNWTMIDAH WKKAKADKTR IWLNEAALRW TPCVYTPSKD FGVRSPVVSP
TSPNQSSTIT TTPTGVSLAA VGSTIKK
//
