ID W2TBK7_NECAM Unreviewed; 820 AA.
AC W2TBK7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Ligand-gated ion channel {ECO:0000313|EMBL:ETN78979.1};
GN ORFNames=NECAME_00352 {ECO:0000313|EMBL:ETN78979.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN78979.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; KI659683; ETN78979.1; -; Genomic_DNA.
DR RefSeq; XP_013301206.1; XM_013445752.1.
DR AlphaFoldDB; W2TBK7; -.
DR STRING; 51031.W2TBK7; -.
DR EnsemblMetazoa; NECAME_00352; NECAME_00352; NECAME_00352.
DR GeneID; 25340396; -.
DR KEGG; nai:NECAME_00352; -.
DR CTD; 25340396; -.
DR OMA; RETITGM; -.
DR OrthoDB; 1034721at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF391; NMDA RECEPTOR 2, ISOFORM C; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 561..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 444..774
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 448..508
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 778..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 820 AA; 91703 MW; 288CC283EDDE32E4 CRC64;
MFLVSDVLNC ICGTLVKNKV ALIIFVTASE TYDTTTAAEQ YFLTLAGYTG IPVIAWNADN
SGFTFGKDLT PYRIIQMAPP IEHQIRAMIA LLQRYSWSKF GVVCSEMAGS SEFIKSVLHE
IADASNKSAK FEIMFHSQLD TSNLTDVDTQ LVELKKSQAK IILLYATTAE ARTIFERASP
LGLTSEKYLW IGTQSVRGTQ TAVTHGHAQP GMLSVNFHTG FIPVSNAMFA PRDDVLPLII
QLAPKLFGAA LLLLPANETM SLQSTASCSE EDGPPSWDDG GKIYECELDR IHALMKQAFV
KGNPFHVDDG HDSFFYTFDK FGKLKNSMLR ISNLRKNPKG GLYWDKVGMF TNNELRMADV
EWPGDKANPP QGTADKFHVK YSVYRRSLSM NCSSFNAKSA RSKLADLSRL SPYTNHRSLS
FPTSTRTPVG VLEIKGVSVI GVMRRSTPLE GGKQNRTLWK CCSGYCVDLL NKLANDIGFT
YTLYKVRDEK WGLKTETGWN GLIADLINNK ADMCVTSLKL NSERARDIDF SLPFLETGIA
IIVKIRSGVL SPTAFLEPFE YSTWVVILLV SIQGAAFAIF IFEWVSPYSF NMSRYPPPDH
KFSLCRSYWL VWATLFSASV STDVPKSTVS RCMALVWAAF GLTFLAVYTA NLAAFMITRV
QFYDLSGIHD PLLAYPADHK PPFRFGTVDG GNTHETMKRN WKKMLTYVQK NRFFRDNISA
GVEAVRNDEL DAFIYDAVVL DYWAGKDANC ELMMAMGKSL TLPEAVDRVQ EWRSRAQSLA
SSQQSPVLKR GYSGVPKQPR PSCRPDYKSK GRFLEVETNL
//
