ID   W2TDD3_NECAM            Unreviewed;       774 AA.
AC   W2TDD3;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Pyridoxal-dependent decarboxylase domain protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=NECAME_09617 {ECO:0000313|EMBL:ETN79818.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC   Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN79818.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KI659330; ETN79818.1; -; Genomic_DNA.
DR   RefSeq; XP_013302045.1; XM_013446591.1.
DR   AlphaFoldDB; W2TDD3; -.
DR   STRING; 51031.W2TDD3; -.
DR   EnsemblMetazoa; NECAME_09617; NECAME_09617; NECAME_09617.
DR   GeneID; 25349646; -.
DR   KEGG; nai:NECAME_09617; -.
DR   CTD; 25349646; -.
DR   OMA; PEHSQYG; -.
DR   OrthoDB; 3142408at2759; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   PANTHER; PTHR42735; -; 1.
DR   PANTHER; PTHR42735:SF1; PYRIDOXAL-DEPENDENT DECARBOXYLASE DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          724..774
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        738..756
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   774 AA;  85775 MW;  679716FAA3090CC0 CRC64;
     MKGYKIDQQS QPSPGSHTSS TRSHDSGVED GSTKNAVPTK PLSRKTSRMS QYNVSPVLEQ
     LQNLIISDEW VGKEAPQFQP QLTKTRSRES QHLSDLGRTL ITSSSLKAYI DLLSSQHKQS
     IASWLYGNTS QALGQQFRFP EANVYCSEPE ATLALSVRNG IGHAIRLALK DTYGSDYVGK
     GWKAFVEQGA PVIYVTPALH MDLASYIATE FGIADVVLLP KLEGDMSEIE GRINHHAFER
     ILDEDVAAGR RPLLVVAVVG STILGQNDMV SKILEIRKKH PFWLHTVGQA MAALTLREPA
     EVLVHVLTQV DSVTLPLALW LGIPAAPVVT LHRAVEGHKL SYREKLETLP WWVATQTITS
     KGITDIIENS YLLCKVMLKG LSSFPQIEII GMDNAVEFAT KVCKNQYTAP TVLIFKYRYA
     AAKEAAKTLR ELSQKSEGEL NKDAIARAEN IFRDEAEYSD SLNSWLGQGV VAECQSLGIH
     IIELGGSYGA AFRFCPLEHA ASLFTALQSH VDHVQQFIRL LGGVLKIVHS TVAARANFAK
     LKSEYPSLTL LPIQKWAGVG AVCYVPSIVK SKTPSDWDEK EKQQISHMNS ELVHQLRSVD
     SAFSTGESSM FGVACVKFGM LSDAKDLADL LKMVAEKGKE IETNQQYLDS LAELIRQGIE
     AANEDLKKEN DLRLQQEGVI RQLPIMGSLV NWWSPLEKDG RIRGRFFNLN TGEIQTTDVI
     YKHKRESHAT SHGVKSRVPG ESKNEQKDKD VELPNQEITA EKPTVEQPTS IEEK
//