ID W2TF61_NECAM Unreviewed; 218 AA.
AC W2TF61;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=SH3 domain protein {ECO:0000313|EMBL:ETN79662.1};
GN ORFNames=NECAME_09671 {ECO:0000313|EMBL:ETN79662.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN79662.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI659382; ETN79662.1; -; Genomic_DNA.
DR RefSeq; XP_013301889.1; XM_013446435.1.
DR AlphaFoldDB; W2TF61; -.
DR STRING; 51031.W2TF61; -.
DR EnsemblMetazoa; NECAME_09671; NECAME_09671; NECAME_09671.
DR GeneID; 25349700; -.
DR KEGG; nai:NECAME_09671; -.
DR CTD; 25349700; -.
DR OMA; WAVKFNS; -.
DR OrthoDB; 25371at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR CDD; cd09941; SH2_Grb2_like; 1.
DR CDD; cd11805; SH3_GRB2_like_C; 1.
DR CDD; cd11804; SH3_GRB2_like_N; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR043539; Grb2-like.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46037:SF1; GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2; 1.
DR PANTHER; PTHR46037; PROTEIN ENHANCER OF SEVENLESS 2B; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 2.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..58
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 60..152
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 154..213
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 218 AA; 25353 MW; DDA7B13EFDAE014F CRC64;
MEATAEHDFN ANADDELSFR RGQILKVLNK DEDPHWFKAE IDGVEGFVPS NYIRMHDSPW
YLGKISRLDA EILLKKQGTR DGNFLVRQCE SSPGDFSISV KFEDTIQHFK VLRDNNGKYF
LWSVKFKSLN ELVRYHRTAS VSRTHTILLQ DLDLETKFVQ ALFDFNPQEE GELPFKRGEI
ITLINKDDMN WWEGSLNNKR GVFPANYVCP FNRSPSNT
//
