ID W2TG24_NECAM Unreviewed; 137 AA.
AC W2TG24;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=TIL domain-containing protein {ECO:0000259|Pfam:PF01826};
GN ORFNames=NECAME_09382 {ECO:0000313|EMBL:ETN80146.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN80146.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI659202; ETN80146.1; -; Genomic_DNA.
DR RefSeq; XP_013302373.1; XM_013446919.1.
DR AlphaFoldDB; W2TG24; -.
DR EnsemblMetazoa; NECAME_09382; NECAME_09382; NECAME_09382.
DR GeneID; 25349411; -.
DR KEGG; nai:NECAME_09382; -.
DR CTD; 25349411; -.
DR OMA; CGPERHC; -.
DR OrthoDB; 2876881at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR Pfam; PF01826; TIL; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 1.
PE 4: Predicted;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900}.
FT DOMAIN 26..88
FT /note="TIL"
FT /evidence="ECO:0000259|Pfam:PF01826"
FT REGION 117..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 137 AA; 16320 MW; ED9C6D64E01531F8 CRC64;
MFLESFQLHR QIPHYPARNE KHAAYCSVRE YHVTCGPERH CDKSCDNMYS PPHCYHDATN
PKCYFPRCLC KEGFVRNALG HCIWEHQCPN RYSEPNKNST DSDGMVMEFV PFVRPRHRAR
KARHPHRHRR LQLEKSA
//
