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Database: UniProt
Entry: W2TI03_NECAM
LinkDB: W2TI03_NECAM
Original site: W2TI03_NECAM 
ID   W2TI03_NECAM            Unreviewed;       493 AA.
AC   W2TI03;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE            EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
GN   ORFNames=NECAME_02128 {ECO:0000313|EMBL:ETN81448.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Ancylostomatoidea; Ancylostomatidae; Bunostominae; Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN81448.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC         Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001062};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC   -!- SIMILARITY: Belongs to the glutaminase family.
CC       {ECO:0000256|ARBA:ARBA00011076}.
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DR   EMBL; KI658727; ETN81448.1; -; Genomic_DNA.
DR   RefSeq; XP_013303675.1; XM_013448221.1.
DR   AlphaFoldDB; W2TI03; -.
DR   STRING; 51031.W2TI03; -.
DR   EnsemblMetazoa; NECAME_02128; NECAME_02128; NECAME_02128.
DR   GeneID; 25342168; -.
DR   KEGG; nai:NECAME_02128; -.
DR   CTD; 25342168; -.
DR   OMA; SHRAFHP; -.
DR   OrthoDB; 537490at2759; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.238.210; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR015868; Glutaminase.
DR   InterPro; IPR041541; Glutaminase_EF-hand.
DR   PANTHER; PTHR12544; GLUTAMINASE; 1.
DR   PANTHER; PTHR12544:SF29; GLUTAMINASE; 1.
DR   Pfam; PF13637; Ank_4; 1.
DR   Pfam; PF17959; EF-hand_14; 1.
DR   Pfam; PF04960; Glutaminase; 2.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW   ProRule:PRU00023}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        468..491
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          20..105
FT                   /note="Glutaminase EF-hand"
FT                   /evidence="ECO:0000259|Pfam:PF17959"
FT   REPEAT          434..456
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ   SEQUENCE   493 AA;  55505 MW;  1F98D583B9EB45FB CRC64;
     MSKTVEGLNH AYELRDSCPE DLIFDLFKMP NRDEASMSKL IKVLKSFGLR ESDPRLRNMM
     EKMKSYEDDD DDARNFLLPR EKFKECIHPS VQLISQALRN HLIIPSWGEF CGQIKTIFEE
     CKAIKDGNVA TYIPQLARQN PEIWGLSICT IDGQRVSFGD SKVPFCVQSV SKAFNYAIVS
     SDLGADFVHS YVGHEPRKPH NPLINAGAII VTSLIRNHLT MADRFLSERD TADRNYALSY
     YMKENKCFPP GTQGLREELD LYFQLCSLEI TCETAAIMAA TLANGGVCPL TDELCIQPRP
     CRDVLSLMYS CGMYDFSGKF AFQVGLPAKS GVSGVMIVVV PNLMGIALFA PPLDRMGNST
     KGVAFCQKLI DTFNFHNYDS LLHADSKKHD PRRRIGNRDT ELVVSLLFAA KHGDFDAVRR
     MYLQGTNLEM ADYDGRTALH VAAAEGHIHL VKFFVNVAKL NHQPRDRYFL ILSYFPVLFM
     KPSLTLGAIL VRV
//
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