ID W2TIM5_NECAM Unreviewed; 409 AA.
AC W2TIM5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=DM DNA binding domain protein {ECO:0000313|EMBL:ETN81016.1};
GN ORFNames=NECAME_08769 {ECO:0000313|EMBL:ETN81016.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN81016.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00070}.
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DR EMBL; KI658873; ETN81016.1; -; Genomic_DNA.
DR RefSeq; XP_013303243.1; XM_013447789.1.
DR AlphaFoldDB; W2TIM5; -.
DR STRING; 51031.W2TIM5; -.
DR EnsemblMetazoa; NECAME_08769; NECAME_08769; NECAME_08769.
DR GeneID; 25348798; -.
DR KEGG; nai:NECAME_08769; -.
DR CTD; 25348798; -.
DR OMA; QMEREPE; -.
DR OrthoDB; 2880558at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 4.10.1040.10; DM DNA-binding domain; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR026607; DMRT.
DR PANTHER; PTHR12322:SF122; DM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12322; DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT; 1.
DR Pfam; PF00751; DM; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF82927; Cysteine-rich DNA binding domain, (DM domain); 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00070};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00070};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00070}; Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00070}.
FT DOMAIN 67..110
FT /note="DM"
FT /evidence="ECO:0000259|PROSITE:PS50809"
FT DNA_BIND 67..110
FT /note="DM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00070"
FT REGION 147..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 409 AA; 44803 MW; 8651B0BD9D456B08 CRC64;
MSGEVVATVP PGTQVVVEAK LLTSDVDHTI EEVRQETIQQ VHEALTVVGQ PIPNLPNARP
PNRTLFCRKC EGHGLQVVLK GHASRCPYNN CQCKTCSNVM SMRANAIIRR YRTRTLEGGL
VLKPVHFKNG NTRLRVFPKY VDESDALPIP MERPREKNPS GDDGSVKSQT MPITPPGHGA
GPFAVKRSFS ETQVDCLQEA EKRSSPKRSY AEPATAGSPV ETSPQPQFAQ YTQPNLLDLL
LKHQLSNHDP ATDLLTQGLL GLPTSCLPIC SLPPYDPPSS TLLASSLSSL PTASLTYSSP
VTSYQNPFLT ASSFINSSST TLEEKEPIIC PTSQLSELSI GISEPPVSEQ QKLTPGMIMI
TGSQMEREPE RFTANLMISP TADKSHPLFK QFLATVRELE KQMLSEFRT
//
