ID W2TIZ3_NECAM Unreviewed; 279 AA.
AC W2TIZ3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=PTB domain protein {ECO:0000313|EMBL:ETN82075.1};
GN ORFNames=NECAME_08174 {ECO:0000313|EMBL:ETN82075.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN82075.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI658576; ETN82075.1; -; Genomic_DNA.
DR RefSeq; XP_013304302.1; XM_013448848.1.
DR AlphaFoldDB; W2TIZ3; -.
DR STRING; 51031.W2TIZ3; -.
DR EnsemblMetazoa; NECAME_08174; NECAME_08174; NECAME_08174.
DR GeneID; 25348204; -.
DR KEGG; nai:NECAME_08174; -.
DR CTD; 25348204; -.
DR OMA; CKIFSIF; -.
DR OrthoDB; 2996885at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR PANTHER; PTHR21258:SF56; INSULIN RECEPTOR SUBSTRATE 1; 1.
DR Pfam; PF02174; IRS; 1.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51064; IRS_PTB; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT DOMAIN 21..124
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
SQ SEQUENCE 279 AA; 31234 MW; A897D8754020FBA5 CRC64;
MGNCVSEDAQ RGHKDFLKNV KCDPEKQVTS FRVYLHRRNK FIHAWLRISA DDVTLERSKT
DIVVWPLQFL RRYGYTSAGV FFFESGRRCP TGEGLHTFQS QNADAIFQLV QSRIQDNANT
HHAETMRRGE RARSTGPTMA TGVSVRCINP IQRYGSEGAG VGSEYLAQPA GYNSYHRGSV
QRLRNVVIPP PPRPRSVGEA EPSCLPPDSF HPHRHNTFVD QRIVGNIVSV STNPSAVDDV
TGRRTSSTSQ HSSHGVFSVP YVNISPQEVF SDCKIFSIF
//
