ID W2TJP4_NECAM Unreviewed; 353 AA.
AC W2TJP4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Nematode cuticle collagen domain protein {ECO:0000313|EMBL:ETN81232.1};
GN ORFNames=NECAME_08672 {ECO:0000313|EMBL:ETN81232.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN81232.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI658811; ETN81232.1; -; Genomic_DNA.
DR RefSeq; XP_013303459.1; XM_013448005.1.
DR AlphaFoldDB; W2TJP4; -.
DR STRING; 51031.W2TJP4; -.
DR EnsemblMetazoa; NECAME_08672; NECAME_08672; NECAME_08672.
DR GeneID; 25348701; -.
DR KEGG; nai:NECAME_08672; -.
DR CTD; 25348701; -.
DR OMA; CPGREGD; -.
DR OrthoDB; 2882577at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0042302; F:structural constituent of cuticle; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR InterPro; IPR002486; Col_cuticle_N.
DR InterPro; IPR008160; Collagen.
DR PANTHER; PTHR24637; COLLAGEN; 1.
DR PANTHER; PTHR24637:SF276; CUTICLE COLLAGEN LON-3; 1.
DR Pfam; PF01484; Col_cuticle_N; 1.
DR Pfam; PF01391; Collagen; 2.
DR SMART; SM01088; Col_cuticle_N; 1.
PE 4: Predicted;
KW Collagen {ECO:0000313|EMBL:ETN81232.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..353
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004825536"
FT DOMAIN 7..57
FT /note="Nematode cuticle collagen N-terminal"
FT /evidence="ECO:0000259|SMART:SM01088"
FT REGION 76..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 353 AA; 35229 MW; A608B4D900CB3C71 CRC64;
MSASGATSGA LLFSGATLLV SLVAAAAIYS QVNSIWSELD AEMNNFKVLT DDLWKDMIGL
GAGTPSNRLR RQSYGGYAAS GAQPPAPTPL SSSVNAYGGG APQNSDYAGS SNTPLSNPSS
NFGFPTGPGS FVPGGNARCV CTMESSCPPG APGATGEPGP DGLDGLDGIP GFDGLDAEDI
SNEAPQGCFT CPQGLPGPQG PSGPPGIRGM RGAKGQSGRP GKDGNPGMPG EMGPPGPPGE
DGHPGKPGDK GDDAEKPVGR PGLRGPPGDQ GPEGPEGTPG RDAYPGPQGP IGEPGVPGYQ
GAAGPDGEEG PPGPQGDVGK DAEYCKCPDR EAHRPLQSPP HGSGYGRKKY RKH
//
