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Database: UniProt
Entry: W2TL63_NECAM
LinkDB: W2TL63_NECAM
Original site: W2TL63_NECAM 
ID   W2TL63_NECAM            Unreviewed;       215 AA.
AC   W2TL63;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=TIMELESS-interacting protein {ECO:0000256|RuleBase:RU366049};
GN   ORFNames=NECAME_00236 {ECO:0000313|EMBL:ETN81886.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Ancylostomatoidea; Ancylostomatidae; Bunostominae; Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN81886.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- FUNCTION: Plays an important role in the control of DNA replication and
CC       the maintenance of replication fork stability.
CC       {ECO:0000256|RuleBase:RU366049}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU366049}.
CC   -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000256|ARBA:ARBA00006075,
CC       ECO:0000256|RuleBase:RU366049}.
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DR   EMBL; KI658623; ETN81886.1; -; Genomic_DNA.
DR   RefSeq; XP_013304113.1; XM_013448659.1.
DR   AlphaFoldDB; W2TL63; -.
DR   STRING; 51031.W2TL63; -.
DR   EnsemblMetazoa; NECAME_00236; NECAME_00236; NECAME_00236.
DR   GeneID; 25340280; -.
DR   KEGG; nai:NECAME_00236; -.
DR   CTD; 25340280; -.
DR   OMA; NYIMEEE; -.
DR   OrthoDB; 2920045at2759; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR   GO; GO:0000076; P:DNA replication checkpoint signaling; IEA:UniProtKB-UniRule.
DR   GO; GO:0031297; P:replication fork processing; IEA:UniProtKB-UniRule.
DR   InterPro; IPR012923; Csm3.
DR   InterPro; IPR040038; TIPIN/Csm3/Swi3.
DR   PANTHER; PTHR13220; TIMELESS INTERACTING-RELATED; 1.
DR   PANTHER; PTHR13220:SF11; TIMELESS-INTERACTING PROTEIN; 1.
DR   Pfam; PF07962; Swi3; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU366049};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU366049};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366049};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT   DOMAIN          49..89
FT                   /note="Chromosome segregation in meiosis protein 3"
FT                   /evidence="ECO:0000259|Pfam:PF07962"
FT   REGION          112..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..141
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..172
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   215 AA;  25310 MW;  20E1FB118F61DB2A CRC64;
     MRHDRLNARR CSIQNPQPHI KFLHSRKAER KGDEFDRLLL PLRLGPLLYE NLSVILKKYE
     HWAHVMFPKL KFEDVVNRCE SLGDRRIVYM TKSRLDMPVS DEDFATRKRK GDEIIVTENN
     EHDSKELRGE TDSDENYYDP LESTKEVTGD GSSFEVNSSL RAQSPRVNSK SQEIDNDMME
     AISESVNYIM EEEQRRREEA ELAMANEIMD DFDMY
//
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