ID   W2TLX6_NECAM            Unreviewed;       602 AA.
AC   W2TLX6;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Intermediate filament tail domain protein {ECO:0000313|EMBL:ETN82639.1};
GN   ORFNames=NECAME_01924 {ECO:0000313|EMBL:ETN82639.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC   Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN82639.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|PIRNR:PIRNR005546, ECO:0000256|RuleBase:RU000685}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KI658411; ETN82639.1; -; Genomic_DNA.
DR   RefSeq; XP_013304866.1; XM_013449412.1.
DR   AlphaFoldDB; W2TLX6; -.
DR   STRING; 51031.W2TLX6; -.
DR   EnsemblMetazoa; NECAME_01924; NECAME_01924; NECAME_01924.
DR   GeneID; 25341964; -.
DR   KEGG; nai:NECAME_01924; -.
DR   CTD; 25341964; -.
DR   OMA; HIQRQST; -.
DR   OrthoDB; 4640531at2759; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 2.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR016451; Intermed_filament_ifa/ifb.
DR   InterPro; IPR001322; Lamin_tail_dom.
DR   InterPro; IPR036415; Lamin_tail_dom_sf.
DR   PANTHER; PTHR45721:SF12; INTERMEDIATE FILAMENT PROTEIN IFA-1; 1.
DR   PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR   Pfam; PF00038; Filament; 2.
DR   Pfam; PF00932; LTD; 1.
DR   PIRSF; PIRSF005546; Intermed_filamnt_Ifb-2; 2.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
DR   PROSITE; PS51841; LTD; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PIRNR:PIRNR005546};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|PIRNR:PIRNR005546};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT   DOMAIN          61..449
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   DOMAIN          482..599
FT                   /note="LTD"
FT                   /evidence="ECO:0000259|PROSITE:PS51841"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          39..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          206..275
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          354..448
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   602 AA;  69701 MW;  FAF735FBFC4A36E1 CRC64;
     MSYSTTQPGG RAPLGGRQAG NVVSQDRMLK IVTEMRSGAG SGLSPFGQNA ASTIRDSRER
     EKKEMSDLND RLASYIEKVR FLEAQNRKLA ADLDALRSKW GKDTHNIRNM YEGELSDAQK
     LIDETNRQRK EMEVQIKKMQ DELAELRRKY EDAVRGRETD RAKIDDLLVH LSNLEAIEVV
     SRTTHRITSD WPHQSELLSF SEPASKKFIF AEINLLKRRI AQLEDEVKRI KQENQRLLSE
     LQRARTDLDQ ETLNRIDYQN QVQTLLEEID FLRRVHDNEI KELQTLASRD TTPENREFFK
     NELSSAIRDI REEYDQITNV HRTDMESWYR LKVQEIQTQS ARQSMEHGYA KEEVKRLRTQ
     LSDLRGKLAD LESRNSLLEK QIQELNYQLE DDQRSYESAL NDRDAQIRKM REECQALMVE
     LQMLLDTKQT LDAEIAIYRK MLEGEENRAG LKQLVEQVVK THAITQETDT ETMRVVKGET
     ASRQSFQRSA KGNVSIHEAS PDGKFIVLQN THRAKDESIG EWKLKRRIDG KREIVYTLPK
     DFVLRAGKSV KIFARNQGVS SPPDQLVYDG EDTFGSGNSV QTILFNKEGE ERATHIQRQS
     NA
//